Abstract
Monoclonal antibodies prepared to human myelin-associated glycoprotein were shown to react with a population of human peripheral blood mononuclear cells. The population is similar to the large granular lymphocytes or natural killer cells defined by antibody Leu 7 (also called HNK-1). The population also includes cells exhibiting the Leu 2 marker for suppressor/cytotoxic T cells. The results indicate a shared antigenicity between the nervous system and the immune system and may be relevant to the pathogenesis of demyelinating diseases.
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- Abo T., Balch C. M. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol. 1981 Sep;127(3):1024–1029. [PubMed] [Google Scholar]
- Abo T., Balch C. M. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol. 1981 Sep;127(3):1024–1029. [PubMed] [Google Scholar]
- Aoki E., Takasaka T., Adachi H., Sato T., Tanaka K. [The experimental and clinical studies on insulin radioimmunoassay kit (CIS INSIK-5)]. Horumon To Rinsho. 1984 Jan;32(1):71–76. [PubMed] [Google Scholar]
- BOYUM A. SEPARATION OF WHITE BLOOD CELLS. Nature. 1964 Nov 21;204:793–794. doi: 10.1038/204793a0. [DOI] [PubMed] [Google Scholar]
- Benczur M., Petrányl G. G., Pálffy G., Varga M., Tálas M., Kotsy B., Földes I., Hollán S. R. Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor. Clin Exp Immunol. 1980 Mar;39(3):657–662. [PMC free article] [PubMed] [Google Scholar]
- Braun P. E., Frail D. E., Latov N. Myelin-associated glycoprotein is the antigen for a monoclonal IgM in polyneuropathy. J Neurochem. 1982 Nov;39(5):1261–1265. doi: 10.1111/j.1471-4159.1982.tb12563.x. [DOI] [PubMed] [Google Scholar]
- Fuchs S., Schmidt-Hopfeld I., Tridente G., Tarrab-Hazdai R. Thymic lymphocytes bear a surface antigen which cross-reacts with acetylcholine receptor. Nature. 1980 Sep 11;287(5778):162–164. doi: 10.1038/287162a0. [DOI] [PubMed] [Google Scholar]
- Gascón P., Zoumbos N. C., Young N. S. Immunologic abnormalities in patients receiving multiple blood transfusions. Ann Intern Med. 1984 Feb;100(2):173–177. doi: 10.7326/0003-4819-100-2-173. [DOI] [PubMed] [Google Scholar]
- Hauser S. L., Bhan A. K., Gilles F. H., Hoban C. J., Reinherz E. L., Schlossman S. F., Weiner H. L. Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen. J Neuroimmunol. 1983 Oct;5(2):197–205. doi: 10.1016/0165-5728(83)90010-3. [DOI] [PubMed] [Google Scholar]
- Hirayama M., Lisak R. P., Kim S. U., Pleasure D. E., Silberberg D. H. Absence of expression of OKT8 antigen on cultured human, calf and rat oligodendrocytes. Nature. 1983 Jan 13;301(5896):152–154. doi: 10.1038/301152a0. [DOI] [PubMed] [Google Scholar]
- Ilyas A. A., Quarles R. H., Brady R. O. The monoclonal antibody HNK-1 reacts with a human peripheral nerve ganglioside. Biochem Biophys Res Commun. 1984 Aug 16;122(3):1206–1211. doi: 10.1016/0006-291x(84)91220-8. [DOI] [PubMed] [Google Scholar]
- Ilyas A. A., Quarles R. H., MacIntosh T. D., Dobersen M. J., Trapp B. D., Dalakas M. C., Brady R. O. IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1225–1229. doi: 10.1073/pnas.81.4.1225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Inuzuka T., Quarles R. H., Noronha A. B., Dobersen M. J., Brady R. O. A human lymphocyte antigen is shared with a group of glycoproteins in peripheral nerve. Neurosci Lett. 1984 Sep 28;51(1):105–111. doi: 10.1016/0304-3940(84)90270-2. [DOI] [PubMed] [Google Scholar]
- Itoyama Y., Sternberger N. H., Webster H. D., Quarles R. H., Cohen S. R., Richardson E. P., Jr Immunocytochemical observations on the distribution of myelin-associated glycoprotein and myelin basic protein in multiple sclerosis lesions. Ann Neurol. 1980 Feb;7(2):167–177. doi: 10.1002/ana.410070212. [DOI] [PubMed] [Google Scholar]
- Lindmark R., Thorén-Tolling K., Sjöquist J. Binding of immunoglobulins to protein A and immunoglobulin levels in mammalian sera. J Immunol Methods. 1983 Aug 12;62(1):1–13. doi: 10.1016/0022-1759(83)90104-7. [DOI] [PubMed] [Google Scholar]
- McGarry R. C., Helfand S. L., Quarles R. H., Roder J. C. Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1. Nature. 1983 Nov 24;306(5941):376–378. doi: 10.1038/306376a0. [DOI] [PubMed] [Google Scholar]
- McKenzie J. L., Dalchau R., Fabre J. W. Biochemical characterisation and localization in brain of a human brain-leucocyte membrane glycoprotein recognised by a monoclonal antibody. J Neurochem. 1982 Nov;39(5):1461–1466. doi: 10.1111/j.1471-4159.1982.tb12592.x. [DOI] [PubMed] [Google Scholar]
- Merrill J., Jondal M., Seeley J., Ullberg M., Sidén A. Decreased NK killing in patients with multiple sclerosis: an analysis on the level of the single effector cell in peripheral blood and cerebrospinal fluid in relation to the activity in the disease. Clin Exp Immunol. 1982 Feb;47(2):419–430. [PMC free article] [PubMed] [Google Scholar]
- Murray N., Steck A. J. Indication of a possible role in a demyelinating neuropathy for an antigen shared between myelin and NK cells. Lancet. 1984 Mar 31;1(8379):711–713. doi: 10.1016/s0140-6736(84)92224-4. [DOI] [PubMed] [Google Scholar]
- Neighbour P. A., Grayzel A. I., Miller A. E. Endogenous and interferon-augmented natural killer cell activity of human peripheral blood mononuclear cells in vitro. Studies of patients with multiple sclerosis, systemic lupus erythematosus or rheumatoid arthritis. Clin Exp Immunol. 1982 Jul;49(1):11–21. [PMC free article] [PubMed] [Google Scholar]
- Oger J., Szuchet S., Antel J., Arnason B. G. A monoclonal antibody against human T suppressor lymphocytes binds specifically to the surface of cultured oligodendrocytes. Nature. 1982 Jan 7;295(5844):66–68. doi: 10.1038/295066a0. [DOI] [PubMed] [Google Scholar]
- Prineas J. W., Kwon E. E., Sternberger N. H., Lennon V. A. The distribution of myelin-associated glycoprotein and myelin basic protein in actively demyelinating multiple sclerosis lesions. J Neuroimmunol. 1984 Jul;6(4):251–264. doi: 10.1016/0165-5728(84)90012-2. [DOI] [PubMed] [Google Scholar]
- Rumpold H., Kraft D., Obexer G., Radaszkiewicz T., Majdic O., Bettelheim P., Knapp W., Böck G. Phenotypes of human large granular lymphocytes as defined by monoclonal antibodies. Immunobiology. 1983 Feb;164(1):51–62. doi: 10.1016/S0171-2985(83)80017-5. [DOI] [PubMed] [Google Scholar]
- Schuller-Petrovic S., Gebhart W., Lassmann H., Rumpold H., Kraft D. A shared antigenic determinant between natural killer cells and nervous tissue. Nature. 1983 Nov 10;306(5939):179–181. doi: 10.1038/306179a0. [DOI] [PubMed] [Google Scholar]
- Steck A. J., Murray N., Meier C., Page N., Perruisseau G. Demyelinating neuropathy and monoclonal IgM antibody to myelin-associated glycoprotein. Neurology. 1983 Jan;33(1):19–23. doi: 10.1212/wnl.33.1.19. [DOI] [PubMed] [Google Scholar]
- Tilden A. B., Abo T., Balch C. M. Suppressor cell function of human granular lymphocytes identified by the HNK-1 (Leu 7) monoclonal antibody. J Immunol. 1983 Mar;130(3):1171–1175. [PubMed] [Google Scholar]
- Timonen T., Saksela E. Isolation of human NK cells by density gradient centrifugation. J Immunol Methods. 1980;36(3-4):285–291. doi: 10.1016/0022-1759(80)90133-7. [DOI] [PubMed] [Google Scholar]
- Traugott U., Reinherz E. L., Raine C. S. Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science. 1983 Jan 21;219(4582):308–310. doi: 10.1126/science.6217550. [DOI] [PubMed] [Google Scholar]
- Weiner H. L., Hauser S. L. Neuroimmunology I: Immunoregulation in neurological disease. Ann Neurol. 1982 May;11(5):437–449. doi: 10.1002/ana.410110502. [DOI] [PubMed] [Google Scholar]

