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Isothermal titration calorimetry (ITC) thermograms of ubiquitin binding to the catalytic domain of AMSH. (a) ITC thermogram of ubiquitin binding to the catalytic domain of AMSH revealing a KD of 19 ± 3 µM. (b) ITC thermogram of Lys63-linked diubiquitin binding to the catalytic domain of AMSH revealing a KD of 19 ± 4 µM. (c) ITC thermogram of a Phe320Ala mutant of the catalytic domain of AMSH binding to ubiquitin revealing a KD of 81 ± 15 µM.
