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. 1985 Mar;82(5):1518–1521. doi: 10.1073/pnas.82.5.1518

Affinity-purified interleukin 2 induces proliferation of large but not small B cells.

J J Mond, C Thompson, F D Finkelman, J Farrar, M Schaefer, R J Robb
PMCID: PMC397294  PMID: 3871950

Abstract

Immunoaffinity-purified interleukin 2 (IL2) stimulated proliferation of large but not small B cells. Stimulation was observed even when B cells were cultured at very low cell densities (3 X 10(4) per microwell containing 0.2 ml of medium). Addition of small numbers of purified splenic T cells did not enhance the IL2-induced B-cell proliferative response. These results suggest that IL2 was not operating through contaminating T cells. B cells cultured with anti-Ig antibody in vitro showed enhanced proliferation when cultured with EL4 thymoma-derived B-cell growth factor but not when cultured with IL2. A direct role for IL2 in B-cell activation is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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