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. 2014 Mar 11;11:22. doi: 10.1186/1742-4690-11-22

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Copyright © 2014 Tsai et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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PBMC (A) and MDM tropism (B) of T/F Envs. Pseudotype viruses bearing T/F Envs from six CP (in blue) and four RP (in red) macaques are tested for their ability to infect peripheral blood mononuclear cells (PBMCs) and monocyte-derived macrophages (MDMs). To control for differences in viral entry, infectivity in macrophages was normalized to that achieved in PBMCs from the same donor. Data shown are for individual Env clones (2–5) from each animal and is the average of at least two independent experiments. The lines represent the median value for each group and an asterisk (*) indicates statistical significance (p < 0.05). NS, not significant; RLU, relative light units.