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. 1985 May;82(9):2925–2929. doi: 10.1073/pnas.82.9.2925

Rearrangement of T-cell receptor beta-chain genes during T-cell development.

W Born, J Yagüe, E Palmer, J Kappler, P Marrack
PMCID: PMC397679  PMID: 3873070

Abstract

The kinetics and order of rearrangements in the gene complex encoding T-cell-receptor beta chains were studied by Southern blot hybridization in a collection of hybridomas derived from fetal thymocytes at various stages of ontogeny (day 14 to day 17). Our results show a steady increase in the frequency of rearranged beta complexes during this period and suggest that these rearrangements occur within the thymus. beta-chain diversity region (D beta) to beta-chain joining region (J beta) joining preceded other types of rearrangements. More complex hybridization patterns consistent with fully rearranged functional beta-chain genes did not begin to accumulate until day 16, 1 day prior to significant surface expression of the receptor protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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