Figure 6. Effects of 11β-HSD1 inhibition/deletion on neointimal lesion formation in Apo-E knockout mice.

A) In Apo-E^−/− mice fed on Western diet, administration of the selective 11β-HSD1 inhibitor compound 544 reduced neointimal lesion size. Mice with transgenic deletion of Apo-E and11β-HSD1 (double knockout, DKO) also had significantly lower neointimal proliferation than Apo-E^−/− mice. Representative sections stained with United States Trichrome are shown as insets (scale bar = 100 μm); arrows indicate internal and external elastic laminae.

B) Selective 11β-HSD1 inhibition also reduced macrophage content, elevated collagen content and had no effect on smooth muscle content of lesions.

Data are mean±SEM for n= 6-8/group and were analysed by un-paired Student’s t-tests. ns indicates non-significant, * indicates p<0.05.