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. 2013 Dec 20;35(4):959–966. doi: 10.1093/carcin/bgt486

Fig. 4.

Fig. 4.

SB431542 blocks UVB-induced migration of dDC. (A) Representative fluorescence-activated cell sorting profile and quantitation of pSmad2+ cells in MHCIIHi CD11c+ DCs isolated from dermis of SKH1 mice 2h after UVB IR pretreated 1h with SB431542 (SB) or acetone (V). (B) Numbers of CD207− and CD207+ CD103+ DC subsets in SDLNs of SKH1 mice 72h post-UVB IR with 1h pretreatment with SB431542 or vehicle. (C) Percentages of indicated DC subsets in SDLN 72h after UVB IR with 1h pretreatment with SB431542 or acetone (V). (D) Effect of SB432541 on UVB IR-induced migration of DCs in ear explant culture 72h post-UVB. n = 2–3, controls; n = 3–4, UVB IR groups. Error bars = ±SEM. *P < 0.05 relative to indicated group; **P < 0.01 relative to control mice or indicated group.