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. 1985 Jun;82(12):4230–4234. doi: 10.1073/pnas.82.12.4230

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

J M Depper, W J Leonard, C Drogula, M Krönke, T A Waldmann, W C Greene
PMCID: PMC397970  PMID: 2987968

Abstract

We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression had markedly declined. The IL-2-induced increase in IL-2 receptor number is maximal within 12 hr, requires new RNA and protein synthesis, and is mediated by an interaction of ligand with the high-affinity receptors for IL-2. IL-2 stimulation results in increased accumulation of IL-2 receptor mRNA within 4 hr, while an increase in IL-2 receptor gene transcription is detected within 30 min in isolated nuclei. In addition, IL-2 incubation results in increased amounts of c-myc and transferrin receptor mRNA, but it does not augment levels of mRNA encoding the beta chain of the T-cell receptor for antigen. These results demonstrate that IL-2 can directly upregulate transcription and expression of its own receptor and, therefore, indicate that IL-2 may regulate IL-2-dependent immune responses, in part, by influencing the expression of IL-2 receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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