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Cocaine CPP after a 1- or 14-day drug-free interval from escalating-dose binge cocaine or saline administration. After 1-day withdrawal from escalating-dose binge cocaine, Ecocaine-Cocaine mice did not develop a significant preference for the side associated with cocaine. In contrast, after 14-day withdrawal from escalating-dose binge cocaine, Ecocaine-Cocaine mice did develop CPP. Saline-Cocaine mice with 1 or 14 day withdrawal did develop CPP to cocaine.
