. 2014 Feb 25;3(2):132–140. doi: 10.4161/adip.28308

Table 2. Pearson correlation coefficients between DNA methylation and mRNA levels at LEP gene promoter CpG sites in subcutaneous (SAT) and visceral adipose (VAT) tissues according to rs2167270 genotype and adjusted for sex.

	SAT			VAT
	ALL^a	GG^a	GA/AA^a	ALL^a	GG^a	GA/AA^a
n	73	30	43	73	30	43
LEP-CpG3	−0.079	0.145	−0.215	0.070	0.286	−0.068
LEP-CpG4	−0.093	0.243	−0.294^†	0.201	0.266	0.194
LEP-CpG5	−0.060	0.318^†	−0.300^†	0.173	0.294	0.061
LEP-CpG6	−0.051	0.267	−0.239	0.211^†	0.350^†	0.093
LEP-CpG7	−0.076	0.228	−0.249	0.320*	0.575**	0.139
LEP-CpG11	−0.056	0.018	−0.070	0.290*	0.390*	0.238
LEP-CpG12	−0.124	0.004	−0.239	0.086	0.281	−0.039
LEP-CpG13	−0.057	0.192	−0.206	0.308*	0.627**	0.125
LEP-CpG14	−0.126	0.324^†	−0.497**	0.222^†	0.322^†	0.147
LEP-CpG15	−0.065	0.328^†	−0.285^†	0.180	0.281	0.097
LEP-CpG16	−0.093	0.031	−0.173	0.125	0.371*	0.003
LEP-CpG17	−0.172	0.078	−0.367*	0.103	0.212	0.014
LEP-CpG23	−0.168	0.083	−0.340*	0.225^†	0.200	0.256
LEP-CpG24	−0.134	0.202	−0.333*	0.114	0.117	0.116
LEP-CpG25	−0.093	0.329^†	−0.345*	0.193	0.152	0.207
LEP-CpG26	0.048	0.395*	−0.194	0.268*	0.282	0.264
LEP-CpG27	0.006	0.315	−0.238	0.301*	0.250	0.352
LEP-CpG28	−0.012	0.069	−0.090	0.265*	0.351^†	0.180
LEP-CpG29	−0.036	0.203	−0.217	0.252*	0.175	0.322
LEP-CpG30	−0.094	0.117	−0.233	0.215*	0.239	0.212
LEP-CpG31	−0.068	0.079	−0.188	0.172	0.317^†	0.102
LEP-MEAN	−0.060	0.268	−0.265^†	0.297*	0.372*	0.241

^a Adjusted for sex. Statistically significant: **P ≤ 0.05 after corrections for multiple testing; *P ≤ 0.05 and ^†P ≤ 0.10 without correction for multiple testing.