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(a, b) Plasma glucose, (c, d) C-peptide and (e, f) insulin concentrations, and (g, h) ISR per plasma glucose in Study 3. Black circles, baseline; white circles, Week 52. Values are mean ± SEM for sitagliptin 100 mg (a, c, e, g) and canagliflozin 300 mg (b, d, f, h)
