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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Anesthesiology. 2013 Aug;119(2):358–364. doi: 10.1097/ALN.0b013e318291c04e

Figure 4.

Figure 4

Isoflurane anesthesia on postnatal days 4–5 (P4–P5) causes abnormalities in prepulse inhibition (PPI) of the acoustic startle response evaluated at P23–P24. Bumetanide (5 µmol/kg, intraperitoneally), administered prior to anesthesia, alleviated the effect of isoflurane on PPI of acoustic startle. A: Illustration of the experimental protocol. Rats in the control groups did not undergo anesthesia on P4–P5. B: Histogram showing %PPI of startle in different treatment groups: control (n=11), saline + isoflurane (n=14) and bumetanide + isoflurane (n=15). *, P<0.05 vs Control. PP5–PP15 – prepulse intensities in dB above background.