Figure 4.

Src signaling pathways and function. Binding of ligands to the corresponding transmembrane tyrosine kinase receptors (RTK) or intracellular truncated C-terminal isoforms of RTKs can activate Src. Activation of Src is involved in different signaling pathways. Particularly important are the disruption of adherens junctions stabilized by E-cadherin and the disruption of focal adhesions, which promotes migration, invasion and metastasis.