Abstract
Background
Little is known about the use of advance directives (ADs) in patients who have implantable cardiac pacemakers (PMs).
Methods
We conducted a retrospective review of the medical records of residents of Olmsted County, Minnesota, who underwent implantation of a cardiac PM at Mayo Clinic (Rochester, Minnesota) during 2006 and 2007 and determined the prevalence and contents of ADs in these patients.
Results
During the study period, 205 residents of Olmsted County (men, 53%) underwent PM implantation (mean age [SD] at implantation, 77 [15] years). Overall, 120 patients (59%) had ADs. Of these, 63 ADs (53%) were executed more than 12 months before and 33 (28%) were executed after PM implantation. Many patients specifically mentioned life-prolonging treatments in their ADs: cardiopulmonary resuscitation, 76 (63%); mechanical ventilation, 56 (47%); and hemodialysis, 31 (26%). Pain control was mentioned in 79 ADs (66%) and comfort measures were mentioned in 42 ADs (35%). Furthermore, the AD of many patients contained a general statement about end-of-life care (eg, no “heroic measures”). However, only 1 AD (1%) specifically addressed the end-of-life management of the PM.
Conclusions
More than half of the patients with PMs in our study had executed an AD, but only 1 patient specifically mentioned her PM in her AD. These results suggest that patients with PMs should be encouraged to execute ADs and, specifically address end-of-life device management in their ADs. Doing so may prevent end-of-life ethical dilemmas related to PM management.
Keywords: advance directives, end-of-life care, ethics, pacemakers
Introduction
In recent decades, the indications for pacemaker (PM) therapies have expanded. Nonetheless, symptomatic sinus node disease and atrioventricular block continue to be the most common indications for PM therapies (1). These indications often affect elderly persons, and as a result, several hundred thousand PMs are implanted into US patients annually (2). Currently, millions of people in the United States have PMs (3).
Because of the prevalence of patients with PMs, health care professionals who care for them will inevitably encounter patients who have terminal diseases for which the device no longer provides effective therapy (eg, end-stage heart failure) or is nonbeneficial (eg, cancer). Out of concern that the PM will interfere with a natural death, some of these patients or their surrogate decision makers may request PM deactivation—reprogramming the PM so that it does not deliver pacing therapies. Although it is ethically and legally permissible to carry out requests to withdraw PM support (4), the decision to do so can be difficult when a patient is decisionally incapable and the patient’s end-of-life values and preferences, especially about PM management, are unknown.
An advance directive (AD) is a document in which a decisionally capable patient writes his or her values and preferences for health care in the event that he or she loses capacity for making decisions (5). Some ADs allow a patient not only to document health care values and preferences, but also to appoint a surrogate decision maker. Hence, an AD might be helpful in guiding the treatment of patients with a PM who are dying and decisionally incapable. However, little is known about the prevalence and contents of the ADs for patients with a PM. In this retrospective study, we identified residents of Olmsted County, Minnesota, who underwent PM implantation at Mayo Clinic in Rochester, Minnesota, during a 2-year period and ascertained how many of these patients had ADs and whether their ADs addressed end-of-life PM management.
Methods
The Mayo Clinic Institutional Review Board approved this study. The Division of Cardiovascular Diseases at Mayo Clinic in Minnesota prospectively maintains a list of all patients who undergo implantation of cardiovascular electronic implantable devices, including PMs, at our institution. From this list, adult residents of Olmsted County who underwent implantation of a cardiac PM at our institution during 2006 and 2007 were identified. These years were selected to allow up to 4 years for the patients to execute an AD after PM implantation. In 2010, a retrospective review of the medical records of the included patients was conducted. Demographic and clinical data were abstracted from the patients’ medical records by a trained nurse abstractor. The nurse abstractor also identified patients whose ADs were incorporated into their medical records. (At each new outpatient visit and all hospitalizations at Mayo Clinic, patients are asked whether they have ADs and, if so, to submit their ADs for incorporation into their electronic medical records; if not, they are offered AD forms and assistance to complete the ADs.) If more than 1 AD was incorporated into a given patient’s medical record, the most recently executed AD—the legally active AD—was used for this study. Data from each AD were abstracted (eg, type of AD, surrogate, comments regarding life-prolonging treatments). In accordance with Minnesota law (6), we excluded patients who did not authorize the use of their medical records for research purposes. Incarcerated patients were excluded. Because this study was a retrospective analysis of medical records, no patients were contacted.
Statistical Analysis
The statistical methods used in this study were similar to those used in a study involving patients with implantable cardioverter-defibrillators (ICDs) and conducted by our research team (7). Descriptive statistics were used to summarize the study patients’ demographic, clinical, and death data. Overall group data were summarized, and data were also stratified into 2 subgroups according to the presence or absence of an AD in the medical record. Subgroup data were also summarized. To test for an association with having an AD in the medical record, the subgroups were compared using 2-sample t test for continuous variables and the Fisher exact test or the χ2 test for categorical variables. JMP statistical software version 8 (SAS Institute Inc) was used to perform all analyses. A P value <.05 was deemed statistically significant.
Results
During 2006 and 2007, a total of 205 residents of Olmsted County underwent implantation of a cardiac PM at our institution. Indications for PM implantation were atrioventricular block (109 patients [53%]), sinus node dysfunction (76 patients [37%]), carotid sinus hypersensitivity (8 patients [4%]), diffuse conduction disease (8 patients [4%]), and syncope of unknown cause (4 patients [2%]). Seventy-two patients (35%) were PM dependent.
Demographic data are summarized in Table 1. The mean (SD) age of patients at the time of PM implantation was 77 (15) years. About half (53%) were men. Overall, 120 patients (59%) had ADs. Patients who had ADs were significantly older at PM implantation than patients who did not have ADs (82 vs 70 years; P<.001). A greater percentage of patients who had ADs were white than patients who did not have ADs (99% vs 91%; P=.003). Patients with ADs did not differ from patients without ADs concerning sex, relationship status, education, or religion or smoking or alcohol use (data not shown).
Table 1.
Characteristica | All Patients (N=205) | Subgroup
|
P Value | |
---|---|---|---|---|
With AD (n=120) | No AD (n=85) | |||
Age at pacemaker implantation, mean (SD), y | 77 (15) | 82 (9) | 70 (18) | <.001 |
Men | 109 (53) | 64 (53) | 45 (53) | .96 |
Race | .003 | |||
White | 196 (96) | 119 (99) | 77 (91) | |
Other than white | 9 (4) | 1 (1) | 8 (9) |
Abbreviation: AD, advance directive.
Values are expressed as number and percentage of patients unless specified otherwise.
Clinical data are summarized in Table 2. Half of the study patients had coronary artery disease. Compared with patients who did not have ADs, those who had ADs were more likely to have a history of transient ischemic attack (15% vs 4%; P=.008), stroke (23% vs 11%; P<.02), hypertension (86% vs 74%; P=.04), cancer (58% vs 32%; P<.001), and dementia (23% vs 4%; P<.001). Of note, compared with patients who did not have ADs, those who had ADs were not more likely to be PM dependent or to have undergone their first device implantation.
Table 2.
Characteristica | All Patients (N=205) | Subgroup
|
P Value | |
---|---|---|---|---|
With AD (n=120) | No AD (n=85) | |||
PM dependent | .55 | |||
Yes | 72 (35) | 40 (56) | 32 (44) | |
No | 133 (65) | 80 (60) | 53 (40) | |
Coronary artery disease | .29 | |||
Yes | 103 (50) | 64 (53) | 39 (46) | |
No | 102 (50) | 56 (47) | 46 (54) | |
Prior myocardial infarction | .16 | |||
Yes | 43 (21) | 28 (23) | 15 (18) | |
No | 160 (78) | 92 (77) | 68 (80) | |
Unknown | 2 (1) | 0 (0) | 2 (2) | |
Congestive heart failure | .44 | |||
Yes | 91 (44) | 56 (47) | 35 (41) | |
No | 114 (56) | 64 (53) | 50 (59) | |
Renal insufficiency and/or failure | .72 | |||
Yes | 68 (33) | 41 (34) | 27 (32) | |
No | 137 (67) | 79 (66) | 58 (68) | |
History of hemodialysis | .67 | |||
Yes | 6 (3) | 3 (3) | 3 (4) | |
No | 199 (97) | 117 (98) | 82 (96) | |
COPD | .09 | |||
Yes | 35 (17) | 25 (21) | 10 (12) | |
No | 170 (83) | 95 (79) | 75 (88) | |
TIA | .008 | |||
Yes | 21 (10) | 18 (15) | 3 (4) | |
No | 184 (90) | 102 (85) | 82 (96) | |
Stroke | .03 | |||
Yes | 36 (18) | 27 (23) | 9 (11) | |
No | 169 (82) | 93 (78) | 76 (89) | |
Hypertension | .04 | |||
Yes | 166 (81) | 103 (86) | 63 (74) | |
No | 39 (19) | 17 (14) | 22 (26) | |
Hyperlipidemia | .37 | |||
Yes | 128 (62) | 78 (65) | 50 (60) | |
No | 77 (38) | 42 (35) | 35 (41) | |
Diabetes mellitus | .58 | |||
Yes | 49 (24) | 27 (23) | 22 (26) | |
No | 156 (76) | 93 (78) | 63 (74) | |
Cancer | <.001 | |||
Yes | 96 (47) | 69 (58) | 27 (32) | |
No | 109 (53) | 51 (43) | 58 (68) | |
Depression | .34 | |||
Yes | 68 (33) | 43 (36) | 25 (29) | |
No | 137 (67) | 77 (64) | 60 (71) | |
Dementia | <.001 | |||
Yes | 30 (15) | 27 (23) | 3 (4) | |
No | 175 (85) | 93 (78) | 82 (96) | |
Sleep apnea | .93 | |||
Yes | 50 (24) | 29 (24) | 21 (25) | |
No | 155 (76) | 91 (76) | 64 (75) | |
Patient’s first device | .15 | |||
Yes | 143 (70) | 79 (66) | 64 (75) | |
No | 62 (30) | 41 (34) | 21 (25) | |
Feeding tube | .48 | |||
Yes | 7 (3) | 5 (4) | 2 (2) | |
No | 198 (97) | 115 (96) | 83 (98) |
Abbreviations: AD, advance directive; COPD, chronic obstructive pulmonary disease; PM, pacemaker; TIA, transient ischemic attack.
Values are expressed as number and percentage of patients.
Death data are summarized in Table 3. As of January 2010, 35 patients (17%) had died. Although more patients with ADs had died than patients without ADs, this difference was not significant (20% vs 13%; P=.19). No patient underwent PM deactivation before death.
Table 3.
Characteristica | All Patients (N=205) | Subgroup
|
P Value | |
---|---|---|---|---|
AD (n=120) | No AD (n=85) | |||
Status in 2010 | .19 | |||
Alive | 170 (83) | 96 (80) | 74 (87) | |
Dead | 35 (17) | 24 (20) | 11 (13) | |
CPR done before death | .03 | |||
Yes | 1 (3) | 0 (0) | 1 (9) | |
No | 32 (91) | 24 (100) | 8 (73) | |
Unknown | 2 (6) | 0 (0) | 2 (18) | |
Pacemaker deactivated before death | .02 | |||
Yes | 0 (0) | 0 (0) | 0 (0) | |
No | 25 (71) | 20 (83) | 5 (45) | |
Unknown | 10 (29) | 4 (17) | 6 (55) |
Abbreviations: AD, advance directive; CPR, cardiopulmonary resuscitation.
Values are expressed as number and percentage of patients.
Of the 120 patients who had ADs, 63 patients (53%) executed their ADs 12 months or more before PM implantation; 9 (8%) executed their ADs between 6 and 12 months before PM implantation; 9 (8%) executed their ADs 6 months or less before PM implantation; 6 (5%) executed their ADs the day of PM implantation; and 33 (28%) executed their ADs after PM implantation. Many patients identified surrogate decision makers in their ADs. Forty patients (33%) named their spouse, 38 (32%) named a child, 2 (2%) named a friend, and 23 (19%) named a person whose relationship to the patient was indeterminate. Seventeen patients (14%) did not identify a surrogate decision maker. Many patients also identified alternate surrogates. Forty-eight (40%) patients named a child, 3 (3%) named a friend, and 31 (26%) named a person whose relationship to the patient was indeterminate. Thirty-eight patients (32%) did not identify an alternate surrogate.
The types of ADs executed by the study patients and the life-prolonging treatments specifically mentioned in their ADs are listed in Table 4. A majority (75%) of patients executed a “combined” AD—an AD with features of a power of attorney for health care and living will (5). Many patients mentioned life-sustaining treatments in their ADs, including cardiopulmonary resuscitation (63%), mechanical ventilation (47%), and hemodialysis (26%). Pain control was mentioned in two-thirds of the ADs and comfort measures in about one-third. Only 1 patient (1%) explicitly mentioned her PM in her AD. This patient, who was PM dependent, had a combined AD. In her AD, she specifically wrote “comfort care” as an end-of-life goal. She expressed that she did “not want to be hooked to machine to keep me alive by my pacemaker” [sic]. The patient also wrote that she wanted “to be kept comfortable, no artificial life support [and] allow for natural death.”
Table 4.
Characteristic | ADs, No. (%) |
---|---|
Type of AD | |
Living will | 0 (0) |
Power of attorney | 15 (13) |
Combined (living will and power of attorney) | 90 (75) |
Miscellaneous | 15 (13) |
Pacemaker management | |
Yes | 1 (1) |
No | 100 (83) |
No answer or does not apply | 19 (16) |
Cardiopulmonary resuscitation | |
Yes | 76 (63) |
No | 35 (29) |
No answer or does not apply | 9 (8) |
Mechanical ventilation | |
Yes | 56 (47) |
No | 44 (37) |
No answer or does not apply | 20 (17) |
Dialysis | |
Yes | 31 (26) |
No | 69 (58) |
No answer or does not apply | 20 (17) |
Autopsy | |
Yes | 42 (35) |
No | 65 (54) |
No answer or does not apply | 13 (11) |
Anatomical gift | |
Yes | 19 (16) |
No | 83 (69) |
No answer or does not apply | 18 (15) |
Organ donation | |
Yes | 52 (43) |
No | 49 (41) |
No answer or does not apply | 19 (16) |
Comfort measures | |
Yes | 42 (35) |
No | 58 (48) |
No answer or does not apply | 20 (17) |
Pain control | |
Yes | 79 (66) |
No | 22 (18) |
No answer or does not apply | 19 (16) |
Abbreviation: AD, advance directive.
Although only 1 patient mentioned her PM in her AD, many patients had general statements regarding their end-of-life values and preferences in their ADs. Examples of these statements are listed in the Box.
Box. Examples of General Statements Regarding End-of-Life Management in Advanced Directives of Patients With Pacemakers.
|
Abbreviation: CPR, cardiopulmonary resuscitation.
Discussion
All patients with PMs eventually have terminal cardiac or noncardiac illnesses for which their devices are no longer effective or are nonbeneficial. Some dying patients with PMs, or their surrogate decision makers, may come to regard the devices as impediments to a natural and peaceful death and, therefore, request PM deactivation. It is ethically and legally permissible for health care professionals to fulfill these requests, assuming patients—and, more likely, surrogate decision makers—are informed of the consequences of, and alternatives to, doing so (4). Nevertheless, decisions to carry out such requests may be challenging for decisionally incapable patients who do not have ADs or have ADs that do not mention the device or its management at the end of life.
We determined the prevalence of ADs among Olmsted County residents who underwent PM implantation during a 2-year period and the contents of their ADs—to our knowledge, the largest study of its kind. A majority (59%) of the patients had executed ADs. Yet, only 1 patient specifically mentioned her PM in her AD. These results are similar to the results of studies involving patients with other implantable cardiac devices—namely, ICDs and left ventricular assist devices—which showed that although 30% to 60% of these patients have ADs, only a few mention their device and its management at the end of life (7–9). Overall, cardiac device–specific advance care planning, which includes executing an A+D and documenting end-of-life values and preferences regarding device management at the end of life, appears uncommon among patients who undergo implantation of these devices.
To avoid ethical dilemmas and to respect a dying patient’s wishes for end-of-life care, the Heart Rhythm Society recommends that patients who undergo cardiac device implantation engage in advance care planning, including executing ADs (4). The European Heart Rhythm Association has made similar recommendations (10). Such planning should occur early and often, before and after device implantation, and when patients’ clinical circumstances have changed. Patients should address device management in their ADs and share their ADs with their potential surrogate decision makers and their clinicians. Doing so promotes respect for the patients’ values and preferences and may prevent ethical conflicts if such patients lose decision-making capacity. Of note, electrophysiologists are not the only health care professionals who can engage patients with PMs in advance care planning. Other physicians and especially primary care physicians, nurses, social workers, and other professionals can engage patients in this process.
Although only 1 patient in our study specifically addressed PM management in her AD, many patients addressed other life-sustaining treatments, such as mechanical ventilation and hemodialysis. In addition, many addressed end-of-life issues, such as comfort measures and pain control. These results are similar to those of prior studies involving patients with ICDs (7) or left ventricular assist devices (9) and heart failure (11). These observations suggest that patients with PMs have thought about end-of-life issues and, if prompted, might address PM management in their ADs as they do other life-sustaining technologies. Nonetheless, in the absence of specific statements in ADs, clinicians might deduce decisionally incapable patients’ values and preferences for end-of-life care from broad or general statements in ADs, such as withdrawing life-sustaining treatments if the patient is approaching death and there is little hope for recovery (see Box). However, evidence suggests that health care professionals prefer statements in patients’ ADs that are treatment specific, especially in conjunction with prior discussions with the patients (12). These discussions and the execution of an AD optimally should occur before PM implantation. Nonetheless, although a majority of patients with ADs in our study executed their ADs before device implantation, nearly a third (28%) executed their ADs after device implantations. These findings emphasize the importance of reviewing a patient’s AD not only at the time of device implantation, but also afterward and especially whenever a patient’s clinical circumstances change.
The patients in our study with ADs were significantly older and were more likely to have chronic diseases (eg, prior stroke, dementia, cancer) than patients without ADs. Several factors might account for these findings. Despite the possible life-threatening reasons for having PMs, older patients may feel more compelled to execute ADs than younger patients. Similarly, patients who have PMs and have comorbid disease may feel more compelled to execute ADs than patients who have PMs and are otherwise healthy. Furthermore, health care professionals may be more inclined to recommend that their older and sicker patients execute ADs. Of note, patients who had ADs were not more likely to be PM dependent than patients who did not have ADs. Nonetheless, many patients who are being evaluated for PM implantation or already have a PM have cardiac conditions that should prompt advance care planning. Such patients should document their values and preferences for end-of-life care in their ADs, including preferences for device management and the names of surrogate decision makers. Patients should also communicate their values and preferences to their loved ones and health care professionals (4).
Of the 35 patients in our study who had died, none underwent PM deactivation. However, during 2008 to 2012, of 150 patients who underwent deactivation of their cardiovascular electronic implantable devices at our institution, 118 patients (79%) underwent deactivation of tachycardia therapies only and 6 patients (4%) who were PM dependent underwent deactivation of bradycardia therapies. All 6 of these latter patients were seriously or terminally ill, 5 lacked decision-making capacity, and none had executed ADs (13). Rather than viewing withdrawal of PM therapies as allowing a natural death (eg, due to the underlying heart disease [14]), some authors have expressed concern about whether withdrawing bradycardia therapies in PM-dependent patients is unethical (ie, whether such withdrawal is a form of assisted death) (15). Nonetheless, about three-quarters of clinicians who care for patients with implantable cardiac devices report having deactivated PMs and only one-tenth of them regard deactivating PMs as euthanasia (16). Furthermore, in our experience, patients or surrogate decision makers may view the PM as prolonging the dying process. To help guide clinicians in these situations, the Heart Rhythm Society sponsored the release of an expert consensus statement on the ethical and legal permissibility of withdrawing cardiovascular implantable electronic device therapies (including PM therapies) in patients who are nearing death or requesting withdrawal of such therapies (4). The statement also provides practical management tips regarding these patients, such as the role of palliative care clinicians. Clinicians who care for patients with a cardiovascular implantable electronic device should be familiar with this statement.
The present study has several limitations. First, the study population was limited to residents of a single county in Minnesota treated at a tertiary medical center and, hence, may not be generalizable to patients elsewhere. Second, it is possible that some patients in our study had executed ADs but did not submit them for inclusion in their medical records. However, we believe the number of such patients is low, given our institution is the only PM-implanting center in southeastern Minnesota and the only center that provides follow-up care for these patients. Also, our systematic approach to asking all patients at new outpatient visits and hospitalizations whether they have executed ADs minimizes the number of patients who have ADs that have not been incorporated into their medical records. Third, the study was retrospective and did not involve contact with patients, surrogate decision makers, or loved ones who might have added relevant data to the study. An important strength of our study is that its findings likely represent the experiences of nearly the entire population of Olmsted County that received PMs during 2006 and 2007, because Mayo Clinic is the only PM-implanting center in southeastern Minnesota.
Future research should focus on means of enhancing advance care planning in patients receiving life-prolonging technologies such as PMs. Research should also identify methods for identifying patients’ health care–related preferences, avoiding unwanted therapies (including those delivered by devices), and palliating symptoms in dying patients who have devices, including those who undergo device deactivation. Finally, research should discern the perspectives of surrogates burdened with decisions about whether to deactivate PMs.
Conclusion
In this study, the largest of its kind, a majority of patients who had PMs had executed ADs. However, only 1 patient mentioned her PM in her AD. Health care professionals who care for patients with PMs should encourage these patients to execute ADs and to specifically mention their preferences for PM management at the end of life in their ADs. Lack of clarity regarding patients’ preferences for end-of-life care, including device management, may result in ethical dilemmas, such as what to do in following requests for PM deactivation in decisionally incapable patients with PMs who are approaching death.
Acknowledgments
This publication was supported by Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. We thank David L. Hayes, MD, for his valuable input regarding this manuscript.
Abbreviations
- AD
advance directive
- ICD
implantable cardioverter-defibrillator
- PM
pacemaker
Footnotes
Presented at the 31st Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2010), Denver, Colorado, May 12–15, 2010. Data from this article were previously presented on May 13, 2010, in a published abstract: Tajouri TH, Ottenberg AL, Mueller PS. The prevalence and use of advance directives among patients with pacemakers. Heart Rhythm. 2010;7(Suppl 5):S192.
Conflicts of interest: Dr. Mueller is a member of the Boston Scientific Patient Safety Advisory Board and is an associate editor for Journal Watch General Medicine.
Authors’ Contributions
Dario Pasalic: data analysis/interpretation, critical revision of article, approval of article, statistics, data collection.
Tanya H. Tajouri: data analysis/interpretation, drafting article, critical revision of article, approval of article, statistics, data collection.
Abigale L. Ottenberg: data analysis/interpretation, drafting article, critical revision of article, approval of article, statistics, data collection.
Paul S. Mueller: concept/design, data analysis/interpretation, drafting article, critical revision of article, approval of article, statistics, data collection.
References
- 1.Kaszala K, Huizar JF, Ellenbogen KA. Contemporary pacemakers: what the primary care physician needs to know. Mayo Clin Proc. 2008 Oct;83(10):1170–86. doi: 10.4065/83.10.1170. [DOI] [PubMed] [Google Scholar]
- 2.Mond HG, Proclemer A. The 11th world survey of cardiac pacing and implantable cardioverter-defibrillators: calendar year 2009: a World Society of Arrhythmia’s project. Pacing Clin Electrophysiol. 2011 Aug;34(8):1013–27. doi: 10.1111/j.1540-8159.2011.03150.x. Epub 2011 Jun 27. [DOI] [PubMed] [Google Scholar]
- 3.Kurtz SM, Ochoa JA, Lau E, Shkolnikov Y, Pavri BB, Frisch D, et al. Implantation trends and patient profiles for pacemakers and implantable cardioverter defibrillators in the United States: 1993–2006. Pacing Clin Electrophysiol. 2010 Jun 1;33(6):705–11. doi: 10.1111/j.1540-8159.2009.02670.x. Epub 2010 Jan 4. [DOI] [PubMed] [Google Scholar]
- 4.Lampert R, Hayes DL, Annas GJ, Farley MA, Goldstein NE, Hamilton RM, et al. American College of Cardiology; American Geriatrics Society; American Academy of Hospice and Palliative Medicine, American Heart Association; European Heart Rhythm Association; Hospice and Palliative Nurses Association. HRS Expert Consensus Statement on the Management of Cardiovascular Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm. 2010 Jul;7(7):1008–26. doi: 10.1016/j.hrthm.2010.04.033. Epub 2010 May 14. [DOI] [PubMed] [Google Scholar]
- 5.Nishimura A, Mueller PS, Evenson LK, Downer LL, Bowron CT, Thieke MP, et al. Patients who complete advance directives and what they prefer. Mayo Clin Proc. 2007 Dec;82(12):1480–6. doi: 10.1016/S0025-6196(11)61091-4. [DOI] [PubMed] [Google Scholar]
- 6.Disclosure of health records for external research. Minn Rev Stat. 2012 § 144.295. [Google Scholar]
- 7.Tajouri TH, Ottenberg AL, Hayes DL, Mueller PS. The use of advance directives among patients with implantable cardioverter defibrillators. Pacing Clin Electrophysiol. 2012 May;35(5):567–73. doi: 10.1111/j.1540-8159.2012.03359.x. Epub 2012 Mar 20. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Berger JT, Gorski M, Cohen T. Advance health planning and treatment preferences among recipients of implantable cardioverter defibrillators: an exploratory study. J Clin Ethics. 2006 Spring;17(1):72–8. [PubMed] [Google Scholar]
- 9.Swetz KM, Mueller PS, Ottenberg AL, Dib C, Freeman MR, Sulmasy DP. The use of advance directives among patients with left ventricular assist devices. Hosp Pract (1995) 2011 Feb;39(1):78–84. doi: 10.3810/hp.2011.02.377. [DOI] [PubMed] [Google Scholar]
- 10.Padeletti L, Arnar DO, Boncinelli L, Brachman J, Camm JA, Daubert JC, et al. European Heart Rhythm Association; Heart Rhythm Society. EHRA Expert Consensus Statement on the management of cardiovascular implantable electronic devices in patients nearing end of life or requesting withdrawal of therapy. Europace. 2010 Oct;12(10):1480–9. doi: 10.1093/europace/euq275. Epub 2010 Jul 30. Erratum in: Europace 2011, Apr 13(4), 599. [DOI] [PubMed] [Google Scholar]
- 11.Dunlay SM, Swetz KM, Mueller PS, Roger VL. Advance directives in community patients with heart failure. Circ Cardiovasc Qual Outcomes. 2012 May;5(3):283–9. doi: 10.1161/CIRCOUTCOMES.112.966036. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Mower WR, Baraff LJ. Advance directives: effect of type of directive on physicians’ therapeutic decisions. Arch Intern Med. 1993 Feb 8;153(3):375–81. doi: 10.1001/archinte.153.3.375. [DOI] [PubMed] [Google Scholar]
- 13.Buchhalter LC, Ottenberg AL, Webster TL, Swetz KM, Hayes DL, Mueller PS. Features and outcomes of patients who underwent cardiac device deactivation. JAMA Intern Med. doi: 10.1001/jamainternmed.2013.11564. In press. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Mueller PS, Hook CC, Hayes DL. Ethical analysis of withdrawal of pacemaker or implantable cardioverter-defibrillator support at the end of life. Mayo Clin Proc. 2003 Aug;78(8):959–63. doi: 10.4065/78.8.959. [DOI] [PubMed] [Google Scholar]
- 15.Huddle TS, Amos Bailey F. Pacemaker deactivation: withdrawal of support or active ending of life? Theor Med Bioeth. 2012 Dec;33(6):421–33. doi: 10.1007/s11017-012-9213-5. [DOI] [PubMed] [Google Scholar]
- 16.Mueller PS, Jenkins SM, Bramstedt KA, Hayes DL. Deactivating implanted cardiac devices in terminally ill patients: practices and attitudes. Pacing Clin Electrophysiol. 2008 May;31(5):560–8. doi: 10.1111/j.1540-8159.2008.01041.x. [DOI] [PubMed] [Google Scholar]