Skip to main content
. 2014 Mar 26;4(6):660–677. doi: 10.7150/thno.8698

Figure 1.

Figure 1

Plasma concentration-time profiles of docetaxel after oral administration to Sprague-Dawley rats at 10 mg/kg dose formulated in the PLGA nanoparticles, PLA-TPGS nanoparticles (NPs), PLGA/montmorillonite NPs, PLA-TPGS/montmorillonite NPs or Taxotere®, compared with the i.v. administration of Taxotere® (n = 5). The therapeutic window is defined as the drug concentration in plasma between the maximum tolerated level (2700 ng/ml) and the minimum effective level (35 ng/ml). Reproduced with permission from Figure 4 of ref. 12 Elsevier Ltd, © (2013).