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. 2013 Dec 11;6(2):409–421. doi: 10.4161/mabs.27457

Table 1. FcγR binding of analyzed antibodies.

  FcγRI § FcγRIIa H131 FcγRIIa R131 FcγRIIb FcγRIIIa V158 FcγRIIIa F158 FcγRIIIb
  KA Fold KA Fold KA Fold KA Fold KA Fold KA Fold KA Fold
IgG1 wt 8,333.33 1.0 1.22 1.0 1.25 1.0 0.42 1.0 4.00 1.0 0.77 1.0 0.09 1.0
S239D/I332E 50,000.00 6.0 5.00 4.1 10.99 8.8 7.14 17 76.92 18 24.39 32 1.76 18.7
S239D/I332E/G236A 22,727.27 2.7 27.78 23 66.67 54 6.67 16 45.45 11 21.74 29 1.42 15.0
wt-fucose -/ -§ 8,333.33 1.0 0.91 0.75 2.50 2.0 0.42 1.0 55.56 13.9 10.20 13.3 n.d. -

KA’s were obtained from global Langmuir fits of Biacore data and are presented in µM−1. Fold = KA(IgG1 wt) / (KA(variant). § KA’s for FcγRI as well as data for wt-fucose −/− were taken from ref. 47.