Table 3. Potency of neutralization of diverse human cytomegalovirus strains by parental and mutant MSL-109 antibodies.
Neutralization IC50 (pM) by IgG variant: | |||
---|---|---|---|
CMV strain | MSL-109 | D53N/T55R | Fold improvement |
VR1814 | 4,850 | 730 | 6.6 |
Brown | 2,560 | 570 | 4.5 |
Dement | 350 | 60 | 5.8 |
Cano | 950 | 190 | 5.0 |
TR | 1,810 | 490 | 3.7 |