Table 7. Dosing and sampling times for each study group.

	Study Day
	Baseline	1	2							3	4	5	8	15	22
	Wed-Fri	Mon	Tues							Wed	Thur	Fri	Mon	Mon	Mon
Rat No.			*	1min	5min	1hr	2hr	4hr	6hr	24hr	48hr	3d	7d	14d	21d
1–4	X	Y	*	X			X			X		X		X
5–8a	X	Y	*		X			X		X		X		X
9–12	X	Y	*			X			X		X		X		X

X, Blood samples were taken via a tail vein. The baseline sample was taken during the week prior to antibody dosing. Blood sample volumes were 400 μL at baseline, day 3 or 4, and day 8 or 15. The other sample volumes were 350 μL. Y, Antibody doses were given in the morning of study day 1. The doses were given in a volume of approximately 3 mL over 2 min via the tail vein. *The METH dose was given SC in a dose of 1 mg/mL in a volume of 1 mL/kg. All subsequent blood sampling times were relative to the METH dosing time. For the 1 and 5 min time points, rats were anesthetized with isoflurane prior to METH administration to ensure timely blood sampling. ^aRats 5 and 6 in each group had blood samples taken on day 3, while rats 7 and 8 had blood samples taken on day 4. Similar sampling occurred on days 5 and 8, and 15 and 22. Thus, there were 6 samples at each time point on days 3 through 22. Four (4) samples were taken at each time point on day 2. Hematocrits were measured at baseline, on days 3 or 4, and days 5 or 8, depending on when each animal’s blood sample was drawn on these days.