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. 2014 Feb 4;53(7):1218–1227. doi: 10.1021/bi401582t

Figure 2.

Figure 2

DNase I footprinting titration experiments that aimed to examine the binding of DB1255 to DNA. (A) Denaturing polyacrylamide gel of the 265 bp 3′-end-radiolabeled DNA fragments incubated with the various tested compounds and (B) the corresponding densitometric analysis. Gray boxes indicate AT-rich tracks of the indicated sequences. Black boxes indicate the ATGA site specific for DB293 (italic) or specifically recognized by DB1255 (bold). G indicates a G-track was performed to localize guanines in the DNA fragment and thus deduce the position of each base within the known 265 bp sequence.