Illustration of the proposed role of DNAJA1
and DnaK on the JNK
pathway and c-Jun phosphorylation. The activation of DNAJA1 through
the interaction with DnaK appears to suppress the JNK pathway, thus
keeping c-Jun in the inactive state. However, inhibiting binding of
DNAJA1 to DnaK, as TIM16 does, would allow for the hyperphosphorylation
of c-Jun, which has an anti-apoptotic effect.