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Illustration of the proposed role of DNAJA1 and DnaK on the JNK pathway and c-Jun phosphorylation. The activation of DNAJA1 through the interaction with DnaK appears to suppress the JNK pathway, thus keeping c-Jun in the inactive state. However, inhibiting binding of DNAJA1 to DnaK, as TIM16 does, would allow for the hyperphosphorylation of c-Jun, which has an anti-apoptotic effect.
