Table 1.
Gene | Known target of | |
---|---|---|
ATF2 | LRH-1 | |
PLK3 | ✓ | ✓ |
GDF15 | ||
FGF21 | * | |
PMM1 | ||
CRELD2 | ✓ | |
NFIL3 | ||
IGSF11 | ||
GSTM2 | ||
GOT1 | ||
DPP9 | ✓ | ✓ |
ST5 | ||
CCBL1 | ✓ | ✓ |
TMEM66 | ✓ | |
KRTCAP2 | ✓ | ✓ |
LRRC59 | ✓ | ✓ |
CDK2AP2 | ✓ | ✓ |
ST3GAL1 | ||
TES | ✓ | |
CCDC134 | ✓ | ✓ |
UGT1L | ||
ACOT2 | ✓ | |
PLIN5 | ✓ | |
LITAF | ✓ | |
RPS13 | ✓ | |
LGALS3BP | ||
CRYM | ||
SUPT5H | ✓ | |
B3GAT3 | ✓ | |
GRN | ✓ | |
ARRDC4 | ||
SLC30A7 | ✓ | |
CRELD1 | ✓ | |
NT5M | ||
ARSG | ||
SEP15 | ||
MKNK1 | ✓ | |
DDX52 | ||
EXOSC5 | ✓ | |
RABAC1 | ✓ | |
RPS15 | ✓ | ✓ |
D830014E11RIK | ||
AVPI1 | ✓ | |
RPS9 | ✓ | |
CRAT | ✓ | |
BHMT2 | ✓ | |
B230217C12RIK | ||
EIF3G | ✓ | ✓ |
SLC25A28 | ✓ | |
HR | ||
CCL9 | ||
ANXA4 | ✓ | ✓ |
SMCO4 | ||
SMOX | ||
ARL14EP | ✓ | |
SLC39A7 | ✓ | |
ICA1 | ||
ENTPD5 | ✓ | |
PIWIL2 | ||
ANG | ✓ | |
MCFD2 | ✓ | ✓ |
SOAT2 | ||
SLC41A3 | ✓ | ✓ |
MFGE8 | ||
CYP4A14 | ||
D12ERTD647E |
Microarray analysis was performed for control and Lrh-1LKO mice treated with vehicle or 1 mg/kg tunicamycin for 24 hr (n = 3). Genes were screened for those induced at least 1.5 fold by TM in control mice with significantly different induction in Lrh-1LKO mice by t-test (p<0.05). This list was filtered for those with differential expression between genotypes with TM treatment by t-test (p<0.05). Previously published genome-wide ATF2 and LRH-1 binding datasets were analyzed to identify genes with ATF2 or LRH-1 binding sites −500 to +275 bp from the TSS. Genes in our set were compared with these sets and genes that contain ATF2 or LRH-1 binding sites meeting the above criteria are marked.
No binding site for ENCODE data set but a known ATF2 direct target (Hondares et al., 2011).