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. 2013 Jun 6;14(4):792–806. doi: 10.1093/biostatistics/kxt020

Fig. 4.

Fig. 4.

Applications. (a) Detrended smoothed observed skin temperature time series recorded from replicate 2 (dotted line) and fitted theoretical oscillation (solid line). (b) SR period estimates for each replicate and each treatment stage in the chronotherapy study (B, Before; D, During; A, After). (c) Detrended observed averaged PER2:LUC normalized luminescence (Norm. lum.) for treatments G1, G2, and control (dashed lines) together with fitted theoretical oscillations (solid line). (d) Relative error plot for individual replicates of PER2:LUC expression for treatments G1, G2, and control using the SR method. (e) Detrended observed average CCA1:LUC and TOC1:LUC normalized luminescence (dashed lines) together with fitted theoretical oscillations (solid line). (f) Relative error plot for individual replicates of the CCA1:LUC and TOC1:LUC constructs using the SR method. In (c) and (e) markers correspond to positions of observed values.