Dear Colleagues and Friends,
The Institute of Human Virology (IHV) at the University of Maryland School of Medicine, the Global Virus Network (GVN), and the Moscow Center for HIV/AIDS Treatment and Prevention welcome you to the Institute’s 15th Annual International Meeting. For only the second time in IHV’s history, the meeting is convening outside of the Baltimore/Washington DC area. This year we gather in Moscow, a city obviously of deep historical significance and home to stunning architecture, cultural tradition, and the Russian Federation Capitol. Further, uniquely this year, the meeting will include presentations from members of the Global Virus Network, thereby broadening the scope of the meeting. The IHV Annual Meeting has fostered international scientific cooperation since its inception. This year's event recognizes both our commitment to the global fight against HIV/AIDS as well as a focus on several other human viral diseases, and the critical roles played by the scientists, physicians, and public health officials in the Russian Federation. We are pleased to join together for hosting this meeting and believe it will impact the future of research on viral diseases in our countries and throughout our network of collaborating institutions.
This year's open meeting is from Sunday, September 8 through Wednesday, September 12. An outstanding program of Russian and international experts in medical virology will be presented in the Moscow City Meeting Hall. While our major focus continues to be in HIV/AIDS, through the Global Virus Network, we will expand the scope to cover other important human viral diseases including hepatitis, measles, influenza, enterovirus, polio and hemorrhagic fever. For each, we concentrate on the latest developments in antiviral drug treatment or preventive vaccines; we also address the roles for viruses in human cancer, how they cause diseases and how they are spread. Workshops provide practical lessons for managing co-morbidities of HIV/AIDS including hepatitis, cancer, tuberculosis and diabetes. Truly, this meeting combines the best knowledge on diagnosis, treatment and prevention of human viral diseases and will be an important event.
We look forward to you joining us in beautiful Moscow to explore the most recent and important developments in HIV/AIDS research and other viral diseases and to acknowledge the progress and challenges in global health research.
Sincerely,
Robert C. Gallo, MD
Director and Professor
Institute of Human Virology and
Co-founder & Scientific Director of the
Global Virus Network (GVN)
Alexey Mazus, MD
Head
Moscow Center for HIV/AIDS Prevention and Treatment
Sharon Hrynkow, PhD
President
Global Virus Network (GVN)
C. David Pauza, PhD
Associate Director and Professor
Institute of Human Virology
Mission Statement
The Institute of Human Virology (IHV) is a world-class center of excellence focusing on chronic viral diseases and virally linked cancers. IHV is dedicated to biomedical research leading to improved treatment and prevention of these diseases.
Our unique structure connects cohesive, multidisciplinary research and clinical programs so that new treatments are streamlined from discovery to patients. IHV is forging local and international programs for research and treatment of human disease.
The IHV is also a Center of Excellence in the Global Virus Network (GVN), and this year’s meeting in Moscow will be immediately followed by a shorter GVN meeting. GVN President, Sharon Hrynkow, is the meeting coordinator with Professor Alexey Mazus.
The mission of the Global Virus Network is to strengthen medical research and response to current viral causes of human disease and to prepare against new viral pandemic threats.
The Moscow Center for HIV/AIDS Prevention and Treatment (AIDS Center) of the Moscow Health Department is the main unit of the city service providing HIV prevention and medical treatment services for Moscow citizens living with HIV/AIDS.
Institute of Human Virology (IHV) Board of Advisors
Terry Lierman (Chair)
Partner, Summit Global Ventures
Rockville, MD
Peter Angelos
Law Office of Peter G. Angelos
Baltimore, MD
Robert Charrow
Greenberg-Traurig, LLP
Washington, DC
Janet Langhart Cohen
Langhart Communications
Chevy Chase, MD
Barbara J. Culliton
Science Journalist and Policy Consultant
Washington, DC
The Honorable Elijah Cummings
US House of Representatives
Baltimore, MD
Mr. John Evans
Evans Telecommunications
Ft. Lauderdale, FL
The Honorable Arthur J. Gajarsa
United States Court of Appeals for the Federal Circuit (Ret)
Washington, DC
Mr. Robert Gray
Chairman, Gray and Company II
Miami Beach, FL
Stewart Greenebaum
Greenebaum & Rose Associates, Inc.
Baltimore, MD
William Hall, MD
University College Dublin
Dublin, Ireland
Ernest F. Hollings
Medical University of South Carolina
Charleston, SC
Harry Huge, Esq.
Harry Huge Law Firm, LLC
Charleston, SC
Mark Kaplan
University of Michigan Medical Center
Ann Arbor, MI
Sheilah A. Kast
WYPR Radio
College Park, MD
The Honorable Nancy Kopp
State Treasurer
Maryland State Government
Annapolis, MD
Reinhard Kurth
Ernst Schering Foundation
Berlin, Germany
Ray Lewis
Ray Lewis Foundation
Baltimore, MD
Mr. Thomas Lynch
Amarin Pharmaceutical, Ltd.
Dublin, Ireland
HRH Princess Chulabhorn Mahidol
Mahidol University
Bangkok, Thailand
Sharon Malone
Fox Hall Ob-Gyn
Washington, DC
Timothy Moynahan
Moynahan & Minella, LLC
Waterbury, CT
Franco Nuschese
Georgetown Entertainment Group
Washington, DC
Joseph Pagano
University of North Carolina at Chapel Hill
Chapel Hill, NC
Peter Palese
Mount Sinai School of Medicine
New York, NY
James Pinkerton
RATE Coalition
Arlington, VA
The Honorable Stephanie Rawlings-Blake
Baltimore City Mayor
Baltimore, MD
Edward “Chip” Robertson
Bartimus, Frickleton, Robertson & Gorny, P.C.
Jefferson City, MO
Kathleen Kennedy-Townsend
The Rock Creek Group
Baltimore, MD
Jeffrey Trammell
Trammel and Company
Washington, DC
Lenny Wilkens
National Basketball Association Hall of Fame Coach and Player
Medina, WA
Steve Wozencraft
John O’Donnell Associates, LLC
New York, NY
Ex-Officio Members
Robert C. Gallo
Director
Institute of Human Virology
Baltimore, MD
William E. Kirwan
Chancellor
University System of Maryland
Adelphia, MD
E. Albert Reece
Dean
University of Maryland, School of Medicine
Baltimore, MD
IHV Scientific Advisory Board
Joseph Pagano, MD (Chair)
University of North Carolina
Edward A. Berger, PhD
National Institutes of Health
Farley R. Cleghorn MD, MPH
Constella Futures
Myron S. Cohen, MD
University of North Carolina
Max Essex, DVM, PhD
Harvard AIDS Institute
Warner Greene, MD, PhD
Gladstone Institute of Virology and Immunology
Mark Kaplan, MD, FACP
University of Michigan
Medical Center
Michel Klein, PhD
Canadian Network for Vaccines and Immunotherapeutics
Erling C. J. Norrby, MD, PhD
The Royal Swedish Academy of Sciences
William Paul, MD
National Institutes of Health
Mario Stevenson, PhD
University of Miami
Sten Vermund, MD, PhD
University of Alabama
Global Virus Network—Centers Of Excellence
AFRICA
South African National Institute for Communicable Diseases (NICD), Division of National Health Laboratory Service (NHLS), Janusz Paweska, BVSC, DVSC*, Robert Swanepoel, BVSC, DTVM, PhD
AUSTRALIA
The Peter Doherty Institute (Melbourne), James McCluskey, MD, PhD, MPH*, Anne Kelso, PhD
ASIA
China Centers for Disease Control, China, Yi Zeng, MD, PhD*
National Institute of Infectious Diseases (NIID-Tokyo), Japan, Hideki Hasegawa, MD, PhD
Amrita Institute of Medical Sciences, India, Prem Nair, MD
EURASIA
Moscow Center for AIDS Prevention, Russia, Alexey Mazus, MD
Mechinov Institute of Vaccines & Sera, Russia, Vitaly V. Zverev, PhD
Chumakov Institute of Poliomyelitis & Viral Encephalitides, Russia, Alexander Lukashev, PhD*
EUROPE
University College Dublin, Ireland, William Hall, PhD*
Autonomous University of Madrid, Spain, Esteban Domingo, PhD, Luis Menendez-Arias, PhD
Ernst Schering Foundation, Germany, Reinhard Kurth, MD*, Robert Koch Institute, Germany, Reinhard Burger, PhD, Technical University of Munich, Germany, Ulrike Protzer, MD, Philipp University Marburg, Germany, Stephan Becker, PhD
University of Padua, Italy, Luigi Chieco-Bianchi, MD, PhD, University of Milano, Italy, Guido Poli, MD, PhD, University of Naples-Nat’l Cancer Institute, Italy, Franco Buonaguro, MD, Luigi Buonaguro, MD, Veterinary Public Health Institute (IZSVe), Italy, Ilaria Capua, DVM, PhD
University of Glasgow, Scotland, United Kingdom, Massimo Palmarini, DVM, PhD, FRSE
Karolinska Institute, Sweden-Baltic, Anders Vahlne, MD, PhD
Gembloux Agro-Biotech, Northern Europe, Arsène Burny, PhD
MIDDLE EAST
Tel Aviv University, Israel, Jonathan Gershoni, PhD
SOUTH AMERICA
National University of La Plata, Argentina, Victor Romanowski, PhD*
NORTH AMERICA/USA
Institute of Human Virology at the University of Maryland, Robert Gallo, MD*, Maria Salvato, PhD, C. David Pauza, PhD, William Blattner, MD, Robert Redfield, MD
Gladstone Institute, University of California San Francisco, Warner Greene, MD, PhD, Eric Verdin, MD
Johns Hopkins University, Maryland, Diane Griffin, MD, PhD
University of Michigan, Mark Kaplan, MD, FACP
University of Texas Medical Branch-Galveston National Labs, James LeDuc, PhD
The Scripps Research Institute, California, Michael Oldstone, MD, Erica Saphire, PhD
Mt. Sinai School of Medicine, New York, Peter Palese, PhD*, Adolfo Garcia-Sastre, PhD
J. Craig Venter Institute, Maryland, David Wentworth, PhD, John Glass, PhD
University of Pittsburgh, Pennsylvania, Patrick Moore, MD, MHP and Yuan Chang
University of Rochester, New York, John Treanor, MD, David Topham, PhD
*Member of the GVN Scientific Leadership Board
Global Virus Network—Board Of Directors
G. Steven Burrill, Chair
Founder and CEO, Burrill & Company
San Francisco, CA 94111
Robert C. Gallo, M.D.
Co-Founder and Chair,
Scientific Leadership Board
Director, Institute of Human Virology
Baltimore, MD
Sharon H. Hrynkow, Ph.D. (Ex officio)
President
Global Virus Network
Baltimore, MD
Gina F. Adams
Senior Vice President,
Government Affairs
FedEx Corporation
Washington, DC
Anthony J. Cernera, Ph.D.
President and CEO
Center for Interreligious Understanding
Fairfield, CT
Andrew Cheng, M.D., Ph.D.
Senior VP HIV Therapeutics & Development Operations
Gilead Sciences, Inc.
Foster City, CA
Nicolas De Santis
President & Secretary General
Gold Mercury International
Mayfair, London
Mathew L. Evins
Chairman, EVINS, Ltd.
New York, NY
N. Scott Fine
Principal, Scarsdale Equities, LLC
New York, NY
William Hall, M.D., Ph.D.
Director, Centre for Research in Infectious Diseases
University College Dublin
Belfield, Dublin 4, Ireland
Salim S. Abdool Karim, M.D., Ph.D.
President, South African Medical Research Council
University of KwaZulu-Natal
Nelson R. Mandela School of Medicine
Durban, South Africa
Reinhard Kurth, M.D., Ph.D.
Chairman of the Foundation Council
Ernst Schering Foundation
Berlin, Germany
Terry L. Lierman
Chair, Board of Advisors
Institute of Human Virology
Chevy Chase, MD
Guenter Lorenz
München, Germany
Charles R. Modica
Chairman of the Board of Trustees and Chancellor
St. George’s University, Grenada, West Indies
c/o University Services LLC
Great River, New York
Timothy Moynahan, Esq.
The Moynahan Law Firm, LLC
Waterbury, CT
Romain Murenzi, Ph.D.
Executive Director
The World Academy of Sciences (TWAS)—for the Advancement of Science in Developing Countries
Trieste, Italy
Franco Nuschese
President, Georgetown Entertainment Group
Washington, DC
Lisa Paulsen
President and CEO, Entertainment Industry Foundation
Los Angeles, CA
mailto:lpaulsen@eifoundation.org
Sajan Pillai
Chief Executive Officer
UST-Global
Aliso Viejo, CA
Jeffrey Schragg, J.D., C.P.A.
Tax Partner, Core Tax Services
BDO, USA
McLean, VA
Raj Shah
Chairman and CEO, CTIS, Inc.
Rockville, MD
Zaid Al Siksek, MHA
Managing Director, TRANSCO
Abu Dhabi, UAE
Longde Wang, M.D.
President, Chinese Preventative Medicine Association
Beijing, China
GVN Senior Advisors
William Haseltine
President of ACCESS Health International, Inc.
Washington, DC
Vinton Cerf
Vice President and Chief Internet Evangelist, Google
Reston, VA 20190
Moscow Center for HIV/AIDS Prevention and Treatment
The Moscow Center for HIV/AIDS Prevention and Treatment (AIDS Center) of the Moscow Health Department is the main unit of the city service providing HIV prevention and medical treatment services for Moscow citizens living with HIV/AIDS. The center was established based on a department of the Clinical Hospital No. 2 for Infectious Diseases which, since 1985, had started receiving first individuals in the Soviet Union identified as HIV/AIDS positive.
The specialists who provided medical treatment to the first HIV/AIDS positive individuals formed the backbone of the AIDS Center team. Today it employs more than 200 people working in its 7 departments. The AIDS Center receives patients from healthcare institutions who need their HIV-positive diagnosis to be confirmed and be further registered with the Center or those with controversial HIV antibody test results. The Center provides all types of specialist medical treatment to the HIV/AIDS positive people. Patients and their relatives can get consulting, methodological and psychological assistance as well.
The major success of the Center has been the implementation in Moscow medical institutions of a program to reduce the risk of a vertical transmission from an HIV-positive mother to her child during pregnancy and birth. It comes to be of particular relevance today when increasing numbers of HIV-positive women decide to have children. The implementation of special innovative prevention programs has lead to more than a six-fold reduction in the probability of an HIV-positive child birth which is now less than 3 percent.
The Center contributes to scientific research, as well as approves and implements new methods of HIV diagnosis and treatment. The AIDS Center coordinates HIV prevention efforts of all Moscow medical facilities and monitors the quality of HIV laboratory diagnosis in Moscow healthcare institutions.
Organizing Committee
The Institute of Human Virology at the University of Maryland School of Medicine is grateful for the assistance provided by our International Organizing Committee
C. David Pauza
Institute of Human Virology
Baltimore, MD, USA
Yiming Shao
Chinese Center for Disease Control and Prevention
Beijing, China
Guido Poli
San Raffaele Scientific Institute
Milan, Italy
Jose Esparza
The Gates Foundation
Seattle, Washington, USA
Anders Vahlne
Karolinska Institute
Stockholm, Sweden
Leonid Margolis
National Institutes of Health
Bethesda, Maryland, USA
John Moore
Weill Cornell Medical College
New York, NY, USA
Diane Griffin
The Johns Hopkins School of Medicine
Baltimore, MD, USA
Robert Eisinger
Office of AIDS Research, NIH
Bethesda, MD, USA
Communications and Press Policy
To enhance the exchange of information and communication among attendees of the Institute of Human Virology Annual International Meeting, in partnership with the Global Virus Network and Moscow, the following must be adhered to by all participants:
All comments at sessions are off-the-record and are not for attribution.
No coverage, reporting or publication of scientific data or presentations at the Institute of Human Virology Annual Meeting is permitted without the written consent of the presenter(s) and Nora Grannell (info below). This rule applies to all forms of media, including blogging.
One-on-one interviews with scientists and media may be arranged by contacting Nora Grannell, Director of Public Relations and Marketing, Institute of Human Virology, (410) 706-1954 or ngrannell@ihv.umaryland.edu.
Special Acknowledgements
National Institute of Allergy and Infectious Diseases (NIAID)
Gilead
Office of AIDS Research
Division of AIDS (DAIDS)
Henry M. Jackson Foundation
Merck
Abbott Molecular
Partec
China National Biotec Group
Profectus Biosciences
Sanofi Pasteur
IHV 2013 Lifetime Achievement Award for Scientific Contributions
Vadim I. Agol, MD, PhD, DSc
Vadim I. Agol is a, if not the, number one polio virologist in the world in terms of the basic science of these viruses. He received an MD diploma cum laude from the 1st Moscow Medical School in 1951 and worked for 5 years at the Karaganda Medical Institute. In 1956 he joined the Institute for Poliomyelitis Research in Moscow (now M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of the Russian Academy of Medical Sciences) as junior researcher and has been associated with this Institute until now (from 1957 as senior researcher, in 1961–2009 as head of Laboratory of Biochemistry, and now as chief researcher at this lab). He received a PhD in 1954 from the first Moscow Medical School and DSc in 1967 from the USSR Academy of Medical Sciences. In 1963 he participated in the organization of the Department of Virology of the Moscow State University, serving there as Docent and in 1969–2012 as Professor. He also established and continues as head of the Department of Virus/Cell Interactions at the Institute of Physical-Chemical Biology of the same University.
His main scientific interests are focused on diverse aspects of molecular and cellular biology of RNA-containing viruses (primarily picornaviruses) such as non-genetic and genetic interactions (co-discovery of complementation between non-enveloped RNA viruses; first biochemical proof of the intermolecular recombination between RNA genomes; demonstration of the existence of the non-replicative mechanism of this process), synthesis of viral proteins (first cell-free system for the faithful translation of picornavirus proteins; structural and functional analysis of translational cis-acting element of picornaviral RNAs; discovery and characterization of non-canonical translation initiation factors required for the synthesis of picornaviral proteins; identification of a protease involved in processing of the viral polyprotein; discovery of picornaviral leader proteins; first translational mapping of the flavivirus genome), replication of viral RNA (first evidence for involvement of host proteins in the synthesis of picornavirus RNA; characterization of viral 2C protein involved in the viral replication; functional and structural characterization of replicative cis-elements of the picornavirus genomes), neurovirulence and attenuation of picornaviruses (first mapping of viral phenotypic traits by recombinational analysis; discovery of dependence of attenuation on modulation of viral translation), cellular response to picornaviral infection (discovery of the ability of picornaviruses to trigger and suppress apoptotic response of the cells; discovery of the ability of picornaviruses to permeabilize the nuclear envelope by different mechanisms; demonstration that major picornavirus-induced cellular damages may be caused by interplay between host defense and viral anti-defenses and may be uncoupled from viral reproduction; proposal on the existence of a distinct set of viral proteins, dubbed security proteins, specifically dedicated to the anti-defensive activities), evolution (roles of changes in attenuation determinants, antigenic properties and recombination in the evolution of vaccine polioviruses; molecular epidemiology of poliomyelitis). He actively participated in the world struggle against polio.
Dr. Agol is an (elected) corresponding member of the Russian Academy of Sciences and Russian Academy of Medical Sciences, Honorary Scientist of Russia, recipient of the Triumph prize in biology and medicine, foreign member of the Bulgarian Academy of Sciences, and also received other national and international awards.
Apart from numerous scientific publications, Dr. Agol has published four books of poetry and a book containing an autobiographical novel of his father, well known Soviet geneticist and philosopher Israel Agol, and his own autobiography.
IHV 2013 IHV Lifetime Achievement Award for Public Service
José Esparza, MD, PhD
José Esparza is an internationally recognized expert on HIV/AIDS, vaccine development and global health. His overall mission has been to harness science to address global health problems, focusing on the discovery, development and delivery of vaccines. No one has done more to advance HIV vaccine development.
Since 2004 he has been with the Bill & Melinda Gates Foundation in Seattle, WA first as Senior Advisor on HIV Vaccines and currently as Senior Advisor on Vaccines. In 2012 he was appointed Adjunct Professor of Medicine at the Institute of Human Virology, University of Maryland School of Medicine.
Previously in 1986, he joined the World Health Organization (WHO) in Geneva, Switzerland, to work on viral diseases with epidemic potential. When WHO launched its Global Program on AIDS (GPA) in 1987, Esparza established and led its Biomedical Research Unit. Later he became the Chief of the WHO/GPA Vaccine Development Unit. In 1996 he transitioned to the newly established United Nations Program on HIV/AIDS –UNAIDS (Geneva, Switzerland) as Coordinator of the WHO-UNAIDS HIV Vaccine Initiative. He became a recognized global leader in the field of HIV vaccines.
From 1974 to 1985 he worked in Caracas, Venezuela, at the Venezuelan Institute of Scientific Research—IVIC, at that time, one of the most important research institutions in Latin America. He served as Professor of Virology, Head of the Laboratory of Biology of Viruses and Chairman of the Center of Microbiology and Cell Biology. During this time he published extensively on rotaviruses associated with gastroenteritis.
He is the author of over 175 papers on different aspects of virology, HIV/AIDS and vaccine development. Esparza has served in numerous national and international scientific advisory committees and boards, receiving numerous awards in recognition to his many contributions to global health. He is a member of the National Academy of Medicine of Venezuela and of the Royal Academy of Doctors of Spain.
He received his MD degree in his native country of Venezuela (1968) and a PhD in Virology and Cell Biology from Baylor College of Medicine in Houston, TX (1974).
He currently lives with his wife in Seattle, WA and has a daughter and grandson.
Previous Recipients of IHV Lifetime Achievement Awards
IHV Lifetime Achievement Award for Scientific Contributions
1999 George Klein, Karolinska Institute, Stockholm, Sweden
2000 Maurice Hilleman, Merck Research Laboratories, Sumneytown, Pennsylvania
2001 Hilary Koprowski, Thomas Jefferson University, Philadelphia, Pennsylvania
2002 Alexander Rich, Massachusetts Institute of Technology, Cambridge, Massachusetts
2003 Jan Svoboda, Institute of Molecular Genetics, Prague, Czech Republic
2004 Paul Zamecnik, Massachusetts General Hospital, Boston, Massachusetts
2005 Manfred Eigen, Max Planck Institute, Göttingen, Germany
2006 Maxine Singer, National Institutes of Health, Bethesda, Maryland
2008 Isaac P. Witz, Tel Aviv University, Tel Aviv, Israel
2010 Dr. Rino Rappuoli, Novartis Vaccines in Sienna, Italy
2011 Max Essex, Harvard AIDS Institute
2012 Thomas A Waldmann, MD, NIH
IHV Lifetime Achievement Award for Public Service
2004 Stewart Greenebaum, Greenebaum and Rose Associates, Inc., Baltimore, Maryland
2006 Martin Delaney, Project Inform, San Francisco, California
2008 John D. Evans, Evans Telecommunication Company and The Honorable Robert K. Gray, Gray and Company II, Miami, FL
2010 Harry Huge, Esq.
2011 Bernadine Healy, MD, NIH
2011 Yi Zeng, PhD, China CDC
One-Time IHV Lifetime Achievement Award for Excellence in Teaching
2010 Michele LaPlaca, Bologna, Italy
IHV Lifetime Achievement Award for Excellence in Medical Education, Clinical Care and Clinical Research
2012 John G. Bartlett, MD Johns Hopkins School of Medicine