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. 2014 Mar 10;155(5):1827–1837. doi: 10.1210/en.2013-1682

Figure 1.

Figure 1.

Kp10-induced LH release in young (Y) and middle-aged (MA) females chronically infused with JB-1 or IGF-I. A1, Temporal LH release in young females injected with 10 nmol/kg Kp10. A2, Temporal LH release in young females injected with 30 nmol/kg Kp10. B1, Temporal LH release in middle-aged females injected with10 nmol/kg Kp10. B2,Temporal LH release in middle-aged females injected with 30 nmol/kg Kp10. C1, AUC for panels A1 and B1. C2, AUC for panels A2 and B2. Arrow reflects time zero and the point in which Kp10 was injected. Values are shown as means ± SEM (n = 4). a, P < .05 vs Y-aCSF; b, P < .01 vs 3 nmol/kg Y-aCSF; c, P < .05 vs MA-aCSF, Y-JB-1. *, P < .001 vs baseline LH values for all groups. Peak LH release occurred in all groups at 10 minutes after the Kp10 injection; **, P < .01 vs young and middle-aged-aCSF controls and middle-aged, IGF-I at 30 minutes.