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. Author manuscript; available in PMC: 2014 Apr 18.
Published in final edited form as: Breast Cancer Res Treat. 2014 Jan 31;144(1):179–184. doi: 10.1007/s10549-014-2851-8

Providers of Follow-Up Care in a Population-Based Sample of Breast Cancer Survivors

Christopher R Friese 1, Kathryn A Martinez 2, Paul Abrahamse 3, Ann S Hamilton 4, John J Graff 5, Reshma Jagsi 3, Jennifer J Griggs 3, Sarah T Hawley 2,3, Steven J Katz 3
PMCID: PMC3991008  NIHMSID: NIHMS558281  PMID: 24481682

Abstract

Purpose

To describe which providers provide breast cancer survivorship care.

Patients and Methods

We conducted a longitudinal survey of non-metastatic breast cancer patients identified by the SEER registries of Los Angeles and Detroit. Multinomial logistic regression examined the adjusted odds of surgeon compared with a medical oncologist follow up or primary care provider compared with medical oncologist follow up, adjusting for age, race/ethnicity, insurance, tumor stage, receipt of chemotherapy, endocrine therapy use, and visit to a medical oncologist at the time of diagnosis. Results were weighted to account for sample selection and non-response.

Results

844 women had invasive disease and received chemotherapy or endocrine therapy. 65.2% reported medical oncologists as their main care provider at four years, followed by PCP/other physicians (24.3%) and surgeons (10.5%). Black women were more likely to receive their follow-up care from surgeons (OR 2.47, 95% CI 1.16–5.27) or PCP/other physicians (OR 2.62, 95% CI 1.47–4.65) than medical oncologists. Latinas were more likely to report PCP/other physician follow up than medical oncologists (OR 2.33, 95% CI 1.15–4.73). Compared with privately-insured women, Medicaid recipients were more likely to report PCP/other physician follow up (OR 2.52, 95% CI 1.24–5.15). Women taking endocrine therapy four years after diagnosis were less likely to report surgeons or PCP/other physicians as their primary provider of breast cancer follow up care.

Conclusions

Different survivorship care patterns based on race/ethnicity and insurance status. Interventions are needed to inform patients and providers on the recommended sources of breast cancer follow up.

Keywords: breast cancer, primary care, chronic illness, race/ethnicity

INTRODUCTION

The current care delivery model for cancer survivorship is unsustainable for three key reasons [1]. First, the number of cancer survivors has increased markedly and will continue to do so due to early detection and treatment advances [2]. Second, the surge in the cancer survivor population coincides with projected shortages of medical oncologists [3,4] and primary care physicians [5,6]. Third, follow-up care remains inadequate or fragmented for many cancer survivors [7].

In the case of breast cancer, it is unclear how women should receive follow-up care after treatment. Breast cancer survivors require follow up to assess for recurrence and late effects of therapy. In particular, women who receive chemotherapy and/or endocrine therapy experience an array of effects, including peripheral neuropathy, osteoporosis, or organ toxicity [811]. Breast cancer survivors receive follow-up care in a number of settings. Yet no current guidelines identify the optimal providers of breast cancer care and the optimal time points for transition. Medical oncologists and primary care providers differ in their perspectives and preferences for breast cancer follow-up care [12,13]. Most survivors receive care from either medical oncologists or primary care physicians; fewer patients receive follow up from surgical oncologists or other providers [14]. There are divergent preferences from patients [15] and oncologists [16] on the ideal source for breast cancer survivorship care.

A better understanding of the types of providers breast cancer patients see in the survivorship period can inform policies targeted to improve the quality and efficiency of survivorship care. Clinicians and researchers must comprehend the survivorship experience from distinct racial/ethnic groups given the differential mortality rates observed [2] in the absence of disparate chemotherapy treatment [17]. The study objective was to examine patterns of follow-up care by patient, disease, and treatment factors in a large, diverse, population-based sample of breast cancer patients treated with endocrine or chemotherapy. The results fill a knowledge gap of the experience of diverse women seeking long-term breast cancer follow up.

PATIENTS AND METHODS

Research Design

This prospective longitudinal study used rapid case ascertainment methods in partnership with two cancer registries that participate in the Surveillance, Epidemiology and End-Results (SEER) program. The data collection protocol has been summarized previously [18]. Eligible women from Los Angeles County and Metropolitan Detroit were surveyed at two time points. Latinas in Los Angeles and black women in both Detroit and Los Angeles were oversampled. Baseline surveys were mailed to participants between June 2005 and February 2007, which was around 9 months after the initial breast cancer diagnosis. Follow-up surveys were mailed around 4 years after initial diagnosis.

After human subjects’ approval at the University of Michigan and parallel approvals in California and Detroit, cases were reported monthly to SEER registries. We notified physicians by mail of our intent to survey their patients. Next, we mailed patients a packet with a cover letter, a printed survey copy, a statement of study risks and benefits, and a $10 cash gift. To encourage high response rates, we modified the methods specified by Dillman [19]. These included a reminder letter, followed by a second survey to non-respondents, followed by a follow-up telephone call.

Study Participants

Women were eligible to participate if they were between 20 and 79 years of age, diagnosed with ductal carcinoma in situ or invasive non-metastatic breast cancer (Stages I–III) between June 2005 and February 2007, and reported to the Los Angeles County or Metropolitan Detroit SEER registries. Surveys were administered in both English and Spanish. Asian women were not included due to a second concurrent active study.

Variables

The outcome variable was patient report of the primary provider breast cancer follow up approximately four years after initial diagnosis; this was obtained from the follow-up survey. Women were asked to identify their main provider of breast cancer follow-up care: medical oncologist, surgeon, or primary care physician (PCP) physician. Women were also given the opportunity to name another type of physician. Due to the small number of write-in options, these physicians were lumped into the PCP category.

SEER registries provided age (in years) and cancer stage at diagnosis (I, II, or III) at the baseline survey period. At baseline, patients provided: race/ethnicity (white, black, Latina), receipt of systemic adjuvant chemotherapy (yes/no), insurance coverage (Medicaid, Medicare, private/other insurance, not insured), education (some high school, completed high school, attended or completed college), and whether they consulted a medical oncologist before their initial breast cancer operation. The follow-up patient survey asked women about their use of endocrine therapy for breast cancer; response choices were never taken, took in the past but no longer, and current use at the time of the survey.

Analyses

First, we measured the proportion of women who reported that medical oncologists, surgeons, or primary care/other physicians were their primary provider of breast cancer care approximately four years after diagnosis. We then examined differences in the proportion of women who saw medical oncologists versus surgeons or PCPs/other provider types by the covariates listed above. We used multinomial regression to determine the adjusted odds of surgeon versus medical oncologist follow up as well as the adjusted odds of PCP/other provider versus medical oncologist follow up. All results were weighted to account for differential probabilities of sample demographics and non-response and were conducted in SAS version 10.1.

RESULTS

Of the 1,536 women who completed both baseline and follow-up surveys, 366 were excluded from this analysis due to non-invasive disease and 86 were excluded due to recurrence by the time of the follow-up survey. Because our analysis was focused specifically on women who received systemic therapy, we excluded the 99 women in the sample who did not report at baseline receipt of either chemotherapy or endocrine therapy. 141 women were also excluded because of missing survey data. The final analytic sample consisted of 844 women.

Sample characteristics are presented in Table 1. The sample’s race/ethnicity was white (43.6%) followed by Latina (40.7%) and black (15.7%). The mean (SD) age of respondents was 56.5(11.4) years. The majority of respondents (61%) reported private insurance coverage, 19.5% reported Medicare coverage, 11.6% received Medicaid, and 8.3% reported no coverage. Most of the sample (69%) received systemic chemotherapy. Four years after diagnosis, 45.3% reported current endocrine therapy use and an additional 28.6% reported previous use. Over 90% of respondents reported a consultation with a medical oncologist before their initial breast cancer operation. Of the 844 women with requisite data for analyses, 65.2% of women reported medical oncologists as the main provider of survivorship care at 4 years, followed by PCP/other physicians (24.3%) and surgeons (10.5%).

Table 1.

Sample Characteristics

PERSONAL FACTORS N Weighted %

Age
 Mean(SD) 56.5(11.4) -

Race:
 White 430 43.6
 Black 186 15.7
 Latina 228 40.7

Insurance Coverage:
 Private or other employer-based insurance 538 60.6
 Medicare 173 19.5
 Medicaid 77 11.6
 No insurance 56 8.3

Education:
 Less than high school 141 23.4
 High school graduate 159 17.8
 Some college or college graduate 544 58.8

DISEASE FACTORS

Stage:
 I 392 40.1
 II 341 43.5
 III 111 15.4

TREATMENT FACTORS

Received Systemic Chemotherapy:
 Yes 566 69.1
 No 278 30.9

Endocrine Therapy Use
 Never 207 26.1
 Past 262 28.6
 Current 375 45.3

Consulted with Medical Oncologist prior to Initial Surgery:
 No 778 8.1
 Yes 66 91.9

Percentages reported are weighted for sample demographics and survey non-response.

Receipt of Follow Up by Provider Type

The multinomial logistic regression model examines two comparative outcomes: receipt of follow-up care by surgeon versus medical oncologists (n=706) and PCP/other versus medical oncologists (n=784) (Table 2). Relative to white women, black women were significantly more likely report follow up with a surgeon (OR: 2.47 95% CI: 1.16–5.27) or PCP/other (OR: 2.62 95% CI:1.47–4.65) versus a medical oncologist. Latinas were significantly more likely than white women to be seen by a PCP/other rather than a medical oncologist (OR: 2.33 95% CI: 1.15–4.73). Relative to women with private insurance coverage, those with Medicaid coverage were significantly more likely to be seen by a PCP/other than by a medical oncologist for follow-up care (OR: 2.52 95% CI:1.24–5.15). Current endocrine therapy use was associated with medical oncologist follow up: compared with women who had never taken endocrine therapy, current endocrine therapy users were less likely to see a surgeon (OR: 0.35 95% CI: 0.14–0.86) or a PCP/other (OR: 0.33 95% CI: 0.17–0.64) than a medical oncologist.

Table 2.

Adjusted multinomial regression model, odds of follow-up care with a surgeon compared with a medical oncologist and odds of follow-up care with a PCP/other compared with medical oncologist

Surgeon vs. Medical Oncologist Follow Up
n=706
PCP/other vs. Medical Oncologist Follow Up
n=784

OR 95% CI OR 95% CI

Age (years) 0.99 0.96–1.03 1.02 0.99–1.05

Race
 White 1.00 1.00
 Black 2.47 1.16–5.27 2.62 1.47–4.65
 Latina 1.36 0.50–3.71 2.33 1.15–4.73

Insurance Coverage
 Private/other 1.00 1.00
 Medicare 2.47 0.88–6.96 1.28 0.64–2.56
 Medicaid 0.94 0.19–4.65 2.52 1.24–5.15
 No insurance 1.67 0.44–6.27 0.93 0.35–2.44

Education
 Less than high school 1.00 1.00
 High school graduate 0.98 0.33–2.92 0.79 0.39–1.62
 Some college or more 1.04 0.41–2.59 0.72 0.38–1.34

Stage
 I 1.00 1.00
 II 0.97 0.46–2.02 1.03 0.55–1.94
 III 0.56 0.20–1.62 0.83 0.34–2.05

Received Systemic Chemotherapy
Yes 1.00 1.00
No 1.58 0.61–4.10 1.14 0.53–2.43

Endocrine Therapy Use
 Never 1.00 1.00
 Past 0.54 0.21–1.36 0.67 0.35–1.26
 Current 0.35 0.14–0.86 0.33 0.17–0.64

PCP: Primary Care Physician

Model adjusted for baseline consultation with medical oncologist before breast cancer surgery and geographic location. Model weighted for sample demographics and survey non-response.

The variables in the multinomial logistic regression model were used to calculate the adjusted proportion of women who reported each type of provider for their follow-up breast cancer care at four years (Figure 1). While the overall majority of women reported medical oncologist follow-up, differences were observed by race/ethnicity: 83% of white women, 77% of Latinas, and 65% of black women reported medical oncologist follow-up (p<.001). Whites and Latinas both reported similar rates of surgeon follow-up (6%), yet 12% of black women saw surgeons. Black women saw PCP/other physicians more often (23%) than Latinas (17%) or white women (11%).

Figure 1.

Figure 1

Adjusted proportions of breast cancer follow-up providers, by race/ethnicity (n=844)

DISCUSSION

In this diverse sample of women treated with systemic chemotherapy or endocrine therapy for invasive breast cancer, most women reported follow-up care by medical oncologists versus surgeons or PCPs/other provider types. However, significant differences in follow up care were observed by race/ethnicity and insurance status. In particular, we found black women were significantly less likely than white women to receive breast cancer follow-up care from a medical oncologist versus any other provider type, regardless of receipt of chemotherapy or endocrine therapy. Latinas, too, were less likely to see a medical oncologist versus any other provider type at follow-up, relative to whites. Different patterns of survivorship care emerge for women based on race/ethnicity and insurance status.

Nationally, surgeons provide a very small amount of breast cancer survivorship care relative to medical oncologists and primary care providers [14]. For women who receive systemic and/or endocrine therapy and who do not experience recurrence, it is unclear what aspects of care surgeons would attend to four years after diagnosis. Yet black women in our sample reported seeing surgeons at twice the rate of Latinas or white women. These findings point to the need to better understand how breast cancer follow up care is delivered across diverse settings.

Endocrine therapy after primary breast cancer treatment is recommended for at least five years [20]. Recent clinical trials confirm significant survival advantages for tamoxifen therapy extended to ten years [21,22]. Yet adherence to five years of therapy is low [2327]. Despite impressive efficacy in reducing recurrence, endocrine therapy is associated with a host of bothersome side effects including, among others, hot flashes, sexual side effects, and arthralgias. Adverse effects often lead women to discontinue therapy [2832]. Previously reported data from the current study suggest that the subset of women eligible for endocrine therapy were more likely to persist with using therapy when reporting medical oncologist follow up [27]. It may be the case that women who persist on endocrine therapy follow up with oncologists for side effect management. Additional studies are needed to understand the processes employed by medical oncologists to support women on endocrine therapy, and disseminate these processes to the range of providers who provide follow-up care in the survivorship setting.

Study Limitations

First, we only asked patients to list their primary source of oncology follow-up care, which precludes our ability to measure the presence of shared care models. Patients seen by a team of providers are more likely to receive recommended care [33,34]. Consequently, a shared care model has recently been proposed as a recommended survivorship care model by both the American Cancer Society and American Society of Clinical Oncology for those patients for whom it is appropriate [11].

Surveys occurred at two time points: approximately nine months and four years after diagnosis. Thus, we are not able to determine whether some patients switched their primary follow-up provider between those time points. For example, women may have transitioned from medical oncologist to primary care three years after treatment. We lack data on possible reasons for a transition, which in some cases may have been appropriate [35]. Future studies to examine use of different providers in breast cancer survivorship care would benefit from more detailed reasons why patients transition from medical oncologists to other providers.

The primary source of study data derives from patient report. While recall bias is possible, the period in which women were asked to recall specific events is narrow enough to suggest reliable estimates. External data would validate these findings and inform future research focused on care patterns of breast cancer survivors. These limitations are presented alongside a large, diverse population-based sample with high response survey rates at two time points.

Implications

In a population-based sample of diverse early stage breast cancer patients, we found important differences in follow-up care by patient and treatment factors. Amidst a demand surge for cancer care, a substantial number of breast cancer survivors who have not experienced recurrence continue to see their medical oncologists for survivorship care four years after initial diagnosis. These results suggest a possible mismatch of needs and resources among breast cancer survivors and available providers. Differences in survivorship care patterns by race/ethnicity require clarification. Specifically, the role of surgical follow up for 12% of black women is unclear in the absence of disease recurrence.

From the perspective of clinical policy development, there is an urgent need for specialties that treat women with breast cancer to reach consensus on transition plans that are acceptable to both providers and patients. Doing so will increase the likelihood of an efficient, patient-centered cancer care delivery system [1]. Care coordination in the survivorship period can optimize outcomes for breast cancer patients, yet care transitions from oncology to non-oncology practices is difficult for both patients and providers [36,37]. Intervention studies have failed to improve outcomes for patients who receive survivorship care plans that are shared across providers [38].

It is important to emphasize the absence of empirical data to develop breast cancer survivorship guidelines. Not all patients need to see a medical oncologist four years after treatment [35]. Primary care providers have indicated their willingness to participate earlier in cancer survivorship care [39]. Suggestions to improve their comfort include ready access to oncology specialists, treatment summaries, and access to imaging. A dialogue among care providers to breast cancer is needed to clarify transition points and care goals. Educational interventions - targeted to patients and providers - are needed to guide decision making for survivorship care. Our data suggest interventions targeted to specific groups based on race/ethnicity and insurance status may prove useful in responsible resource allocation.

Acknowledgments

Funding: This study was supported by Grants R01 CA109696 and R01 CA088370 from the National Cancer Institute (NCI) to the University of Michigan. Dr. Friese was supported by a Pathway to Independence Award from the National Institute for Nursing Research (R00NR01570). Dr. Jagsi was supported by a Mentored Research Scholar Grant from the American Cancer Society (MRSG-09-145-01). Dr. Katz was supported by an Established Investigator Award in Cancer Prevention, Control, Behavioral, and Population Sciences Research from the NCI (K05CA111340). The collection of LA County cancer incidence data used was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885; the NCI’s Surveillance, Epidemiology and End Results (SEER) Program under contract N01-PC-35139 awarded to the University of Southern California, contract N01-PC-54404 awarded to the Public Health Institute; and the Centers for Disease Control and Prevention’s National Program of Cancer Registries, under agreement 1U58DP00807-01 awarded to the Public Health Institute. The collection of metropolitan Detroit cancer incidence data was supported by the NCI SEER Program contract N01-PC-35145.

Footnotes

Ethical standards: the study complied with the ethical standards set forth for human subjects by the University of Michigan, Detroit, and California sites.

Financial Disclosure/Conflict of Interest: The authors declare they have no conflict of interest.

References

  • 1.Levit L, Balogh E, Nass S, et al. Committee on Improving the Quality of Cancer Care. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis. National Academies Press; Washington DC: 2013. [PubMed] [Google Scholar]
  • 2.Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63 (1):11–30. doi: 10.3322/caac.21166. [DOI] [PubMed] [Google Scholar]
  • 3.Erikson C, Salsberg E, Forte G, Bruinooge S, Goldstein M. Future supply and demand for oncologists: challenges to assuring access to oncology services. J Oncol Pract. 2007;3:79–86. doi: 10.1200/JOP.0723601. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Warren JL, Mariotto AB, Meekins A, Topor M, Brown ML. Current and future utilization of services from medical oncologists. J Clin Oncol. 2008;26:3242–3247. doi: 10.1200/JCO.2007.14.6357. [DOI] [PubMed] [Google Scholar]
  • 5.Salsberg E, Grover A. Physician workforce shortages: implications and issues for academic health centers and policymakers. Acad Med. 2006;81:782–787. doi: 10.1097/00001888-200609000-00003. [DOI] [PubMed] [Google Scholar]
  • 6.Starfield B, Fryer GE., Jr The primary care physician workforce: ethical and policy implications. Ann Farm Med. 2007;5:486–491. doi: 10.1370/afm.720. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Arora NK, Reeve BB, Hays RD, SBC, Oakley-Girvan I. Assessment of quality of cancer-related follow-up care from the cancer survivor’s perspective. J Clin Oncol. 2011;29 (10):1280–1289. doi: 10.1200/JCO.2010.32.1554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Ganz PA, Greendale GA, Petersen L, Kahn B, Bower JE. Breast cancer in younger women: reproductive and late health effects of treatment. J Clin Oncol. 2003;21 (22):4184–4193. doi: 10.1200/JCO.2003.04.196. [DOI] [PubMed] [Google Scholar]
  • 9.Carver JR, Shapiro CL, Ng A, et al. American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: cardiac and pulmonary late effects. J Clin Oncol. 2007;25 (25):3991–4008. doi: 10.1200/JCO.2007.10.9777. [DOI] [PubMed] [Google Scholar]
  • 10.Camp-Sorrell D. Cardiorespiratory effects in cancer survivors. Cancer Nurs. 2006;29 (2 Suppl):55–59. doi: 10.1097/00002820-200603002-00019. [DOI] [PubMed] [Google Scholar]
  • 11.McCabe MS, Bhatia S, Oeffinger KC, et al. American Society of Clinical Oncology statement: achieving high-quality cancer survivorship care. J Clin Oncol. 2013;31 (5):631–640. doi: 10.1200/JCO.2012.46.6854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Cheung WY, Aziz N, Noone AM, et al. Physician preferences and attitudes regarding different models of survivorship care: a comparison of primary care providers and oncologists. J Cancer Surviv. 2013;7 (3):343–354. doi: 10.1007/s11764-013-0281-y. [DOI] [PubMed] [Google Scholar]
  • 13.Klabunde CN, Han PK, Earle CC, et al. Physician roles in the cancer-related follow-up care of cancer survivors. Fam Med. 2013;45 (7):463–474. [PMC free article] [PubMed] [Google Scholar]
  • 14.Parmeshwar R, Margenthaler JA, Allam E, et al. Patient surveillance after initial breast cancer therapy: variation by physician specialty. Am J Surg. 2013;206 (2):218–222. doi: 10.1016/j.amjsurg.2012.05.037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Mayer DK, Gerstel A, Leak AN, Smith SK. Patient and provider preferences for survivorship care plans. J Oncol Pract. 2012;8 (4):e80–86. doi: 10.1200/JOP.2011.000401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Potosky AL, Han PK, Rowland J, et al. Differences between primary care physicians’ and oncologists’ knowledge, attitudes and practices regarding the care of cancer survivors. J Gen Intern Med. 2011;26 (12):1403–1410. doi: 10.1007/s11606-011-1808-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Griggs JJ, Hawley ST, Graff JJ, et al. Factors associated with receipt of breast cancer adjuvant chemotherapy in a diverse population-based sample. J Clin Oncol. 2012;30 (25):3058–3064. doi: 10.1200/JCO.2012.41.9564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Janz NK, Mujahid MS, Hawley ST, et al. Racial/ethnic differences in quality of life after diagnosis of breast cancer. J Cancer Surviv. 2009;3 (4):212–222. doi: 10.1007/s11764-009-0097-y. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Dillman DA. Mail Internet Surveys: the tailored design method. 2. Wiley; New York, NY: 2007. [Google Scholar]
  • 20.Burstein HJ, Prestrud AA, Seidenfeld J, et al. American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with endocrine receptor-positive breast cancer. J Clin Oncol. 2010;28 (23):3784–3796. doi: 10.1200/JCO.2009.26.3756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Davies C, Hongchao P, Godwin J, et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 2013;381 (9869):805–816. doi: 10.1016/S0140-6736(12)61963-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Jin H, Tu D, Zhao N, et al. Longer-term outcomes of Letrozole versus placebo after 5 years of tamoxifen in the NCIC CTG MA.17 trial: analyses adjusting for treatment crossover. J Clin Oncol. 2012;30 (7):718–721. doi: 10.1200/JCO.2010.34.4010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Weaver KE, Camacho F, Hwang W, Anderson R, Kimmick G. Adherence to adjuvant hormonal therapy and its relationship to breast cancer recurrence and survival among low-income women. Am J Clin Oncol. 2012;36 (2):181–187. doi: 10.1097/COC.0b013e3182436ec1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Hershman DL, Shao T, Kushi LH, et al. Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Res Treat. 2011;126:529–537. doi: 10.1007/s10549-010-1132-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Hershman DL, Kushi LH, Shao T, et al. Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol. 2010;28 (27):4120–4128. doi: 10.1200/JCO.2009.25.9655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Partridge AH, Lafountain A, Mayer E, et al. Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer. J Clin Oncol. 2008;26:556–562. doi: 10.1200/JCO.2007.11.5451. [DOI] [PubMed] [Google Scholar]
  • 27.Friese CR, Pini TM, Abrahamse PH, et al. Adjuvant endocrine therapy initiation and persistence in a diverse sample of patients with breast cancer. Breast Cancer Res Treat. 2013;138 (3):931–939. doi: 10.1007/s10549-013-2499-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Atkins L, Fallowfield L. Intentional and non-intentional non-adherence to medication amongst breast cancer patients. Eur J Cancer. 2006;42:2271–2276. doi: 10.1016/j.ejca.2006.03.004. [DOI] [PubMed] [Google Scholar]
  • 29.Demissie S, Silliman RA, Lash TL. Adjuvant tamoxifen: predictors of use, side effects, and discontinuation in older women. J Clin Oncol. 2001;19:322–328. doi: 10.1200/JCO.2001.19.2.322. [DOI] [PubMed] [Google Scholar]
  • 30.Fink AK, Gurwitz J, Rakowski W, Guadagnoli E, Silliman RA. Patient beliefs and tamoxifen discontinuance in older women with estrogen receptor-positive breast cancer. J Oncol Pract. 2004;8 (6):e149–157. doi: 10.1200/JCO.2004.11.064. [DOI] [PubMed] [Google Scholar]
  • 31.Aiello Bowles EJ, Boudreau DM, Chubak J, et al. Patient-reported discontinuation of endocrine therapy and related adverse effects among women with early-stage breast cancer. J Oncol Pract. 2012;8 (6):e149–157. doi: 10.1200/JOP.2012.000543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32.Kahn KL, Schneider EC, Malin JL, Adams JL, Epstein AM. Patient centered experiences in breast cancer: predicting long-term adherence to tamoxifen use. Med Care. 2007;45:431–439. doi: 10.1097/01.mlr.0000257193.10760.7f. [DOI] [PubMed] [Google Scholar]
  • 33.Snyder CF, Frick KD, Kantsiper ME, et al. Prevention, screening, and surveillance care for breast cancer survivors compared with controls: changes from 1998 to 2002. J Clin Oncol. 2009;27 (7):1054–1061. doi: 10.1200/JCO.2008.18.0950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Snyder CF, Frick KD, Peairs KS, et al. Comparing care for breast cancer survivors to non-cancer controls: a five-year longitudinal study. J Gen Intern Med. 2009;24 (4):469–474. doi: 10.1007/s11606-009-0903-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Earle CC, Ganz PA. Cancer survivorship care: don’t let the perfect be the enemy of the good. J Clin Oncol. 2012;20 (30):3764–3768. doi: 10.1200/JCO.2012.41.7667. [DOI] [PubMed] [Google Scholar]
  • 36.Hewitt M, Greenfield S, Stovall E. From cancer patient to cancer survivor: Lost in transition. Institute of Medicine, National Academies Press; Washington: 2005. [Google Scholar]
  • 37.Kantsiper M, McDonald EL, Geller G, et al. Transitioning to breast cancer survivorship: perspectives of patients, cancer specialists, and primary care providers. J Gen Intern Med. 2009;24 (Suppl 2):459–466. doi: 10.1007/s11606-009-1000-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Grunfeld E, Julian JA, Pond G, et al. Evaluating survivorship care plans: results of a randomized, clinical trial of patients with breast cancer. J Clin Oncol. 2011;29 (36):4755–4762. doi: 10.1200/JCO.2011.36.8373. [DOI] [PubMed] [Google Scholar]
  • 39.Del Guidice ME, Grunfeld E, Harvey BJ, Piliotis E, Verma S. Primary care physicians’ views of routine follow-up care of cancer survivors. J Clin Oncol. 2009;27:3338–3345. doi: 10.1200/JCO.2008.20.4883. [DOI] [PubMed] [Google Scholar]

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