Figure 2. Transcriptional regulation of non-coding RNAs in JAK-STAT network. In T cells, STAT proteins activate the expression of microRNAs and lincRNAs. (A) In Th17 cells, optimal expression of primary miR-155 transcript requires STAT3 (data from GSE40918; Ciofani et al.78). (B) In Th1 cells, STAT4 directly binds to the LincR-Gng2-5′ locus. In STAT4-deficient CD4+ T cells cultured under Th1 conditions, very little expression of LincR-Gng2-5′ is seen. (Data from GSE48138 and GSE22105; Hu et al. and Wei et al.70,79) (C) Similarly, LincR-Epas1-3′AS is regulated by STAT6 in Th2 cells. (Data from GSE48138 and GSE22105; Hu et al. and Wei et al.70,79).