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letter
. 2013 Aug;101(2):192. doi: 10.5935/abc.20130155

Cardiac Dysfunction Related to Cirrhosis

Odilson Marcos Silvestre 1,, Alberto Queiroz Farias 2, Fernando Bacal 1
PMCID: PMC3998145  PMID: 24030080

Dear Editor,

A systematic review of Mota and Markman Filho1 demonstrates that Doppler echocardiography is indicated in cases of cirrhosis, for investigation of pulmonary and vascular complications of cirrhotic cardiomyopathy. We agree that this test may show cardiac abnormalities related to cirrhosis. In our experience, 184 patients prospectively evaluated showed structural cardiac abnormalities at rest, which correlated with the severity of cirrhosis2. However, the presence of these abnormalities is not sufficient to characterize cirrhotic cardiomyopathy. The criteria for diagnosis are not yet established or validated internationally. Clinical manifestations occur in conditions of stress. At rest, the heart is functionally normal. Hence, Doppler echocardiography at rest is often insufficient to characterize cirrhotic cardiomyopathy.

References

  • 1.Mota VG, Markman B., Filho Echocardiography in chronic liver disease: systematic review. Arq Bras Cardiol. 2013 Mar 22; [Epub ahead of print] [PubMed] [Google Scholar]
  • 2.Silvestre OM, Bacal F, de Souza Ramos D, Andrade JL, Furtado M, Pugliese V, et al. Impact of the severity of end-stage liver disease in cardiac structure and function. Ann Hepatol. 2013;12(1):85–91. [PubMed] [Google Scholar]
Arq Bras Cardiol. 2013 Aug;101(2):192.

Reply

Vitor Gomes Mota, Brivaldo Markman Filho

We are thankful to the statements of Silvestre et al1, with which we agree and have mentioned in the introduction to our manuscript. Recent reviews2,3 that address this issue describe a number of abnormalities on Doppler echocardiography at rest, characterizing cirrhotic cardiomyopathy: E/A ratio < 1; E wave deceleration time > 200 ms, isovolumic relaxation time > 80ms, increased left atrial volume, decreased left ventricular contractility, presence of wall hypokinesia and/or akinesia, increased myocardial mass, lowered ejection fraction (< 55%), among others.

Sincerely,

References

  • 1.Mota VG, Markman B., Filho O ecoDopplercardiograma na doença hepática crônica: revisão sistemática. Arq Bras Cardiol. 2013 Mar 22; [Epub ahead of print] [Google Scholar]
  • 2.Zardi EM, Abatte A, Zardi DM, Dobrina A, Margiotta D, Van Tassell BW, et al. Cirrhotic cardiomyopathy. J Am Coll Cardiol. 2010;56(7):539–549. doi: 10.1016/j.jacc.2009.12.075. [DOI] [PubMed] [Google Scholar]
  • 3.Moller S, Henriksen JH. Cirrhotic cardiomyopathy. J Hepatol. 2010;53(1):179–190. doi: 10.1016/j.jhep.2010.02.023. [DOI] [PubMed] [Google Scholar]

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