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. 2014 May;146(5):1325–1338. doi: 10.1053/j.gastro.2014.01.053

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© 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

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Flvcr1a deficiency affects liver homeostasis after Be(a)P-induced cytochrome synthesis. Data on the liver of Be(a)P-treated Flvcr1a^fl/fl and Flvcr1a^fl/fl;alb-cre mice are shown. Heme (A) and malondialdehyde (MDA) (B) content (n = 6). (C, E) Quantitative real-time polymerase chain reaction analysis of Flvcr1a, Ho-1, and Fpn and of Alas1 and Flvcr1b mRNA level (n = 8). (D) Representative Western blot of L-Ft protein (n = 4). Two-way analysis of variance with Bonferroni post-test analysis was performed. *P < .05; **P < .01; ***P < .001; ****P < .0001.