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. 1996 Feb 6;93(3):1060–1064. doi: 10.1073/pnas.93.3.1060

Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.

J Hu 1, C Seeger 1
PMCID: PMC40030  PMID: 8577714

Abstract

The heat shock protein Hsp90 is known as an essential component of several signal transduction pathways and has now been identified as an essential host factor for hepatitis B virus replication. Hsp90 interacts with the viral reverse transcriptase to facilitate the formation of a ribonucleoprotein (RNP) complex between the polymerase and an RNA ligand. This RNP complex is required early in replication for viral assembly and initiation of DNA synthesis through a protein-priming mechanism. These results thus invoke a role for the Hsp90 pathway in the formation of an RNP.

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