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. Author manuscript; available in PMC: 2014 Oct 17.
Published in final edited form as: Nature. 2014 Apr 9;508(7496):340–344. doi: 10.1038/nature13231

Figure 3. Evaluation of alkene substrates containing a branch point.

Figure 3

Conditions: 10 mol% Pd(CH3CN)2(OTs)2, 4 mol% Cu(OTf)2, 14 mol% ligand, 3 equiv PhB(OH)2. a, Independence of catalyst enantiomer on the conservation of the chiral center during the proposed chain-walking process. b, Accessing distinct diasteromers using a combination of catalyst and substrate controlled asymmetric synthesis. c, Proposed mechanistic origin for the observed formation of 5 from 4. d, Isotopic labeling experiment and analysis.