Apical Ballooning Syndrome (Takotsubo Cardiomyopathy) after Permanent Dual-Chamber Pacemaker Implantation

Abstract

Apical ballooning syndrome, also called takotsubo cardiomyopathy, has been recently reported. It may mimic acute myocardial infarction and is typically observed in postmenopausal women after stressful events. A 75-year-old female after permanent dual chamber pacemaker implant complained of chest pain with repolarization alterations suggesting acute myocardial ischemia. Echocardiography showed a left ventricle with akinesia of the apical portions and reduced global systolic function. The patient was treated with antithrombotic agents and intravenous nitrates. No coronary lesions were found at angiography. At ventriculography, a typical takotsubo-like shape of the left ventricle was observed. The clinical and echocardiographic picture normalized at discharge.

1. Introduction

Apical ballooning syndrome (ABS) has been reported since the 1990s in Japan [1]. The clinical presentation mimics acute myocardial infarction (AMI) and is characterized by chest pain and or dyspnoea, ST segment elevation, mild cardiac enzymes increase, transient left ventricular systolic dysfunction with hypokinesia of the middle and distal portions of the left ventricle (LV) and hyperkinesia of basal segments, and absence of coronary artery lesions. It typically affects postmenopausal women, and the prognosis is usually favourable. An emotional or physical stressful event often precedes the clinical picture [2–4]. We describe a case of ABS which occurred after permanent pacemaker implantation.

2. Case Report

A 75-year-old woman with history of hypertension and no previous cardiac symptoms was admitted for syncope and paroxysmal third-degree atrioventricular (AV) block. Preoperative evaluation revealed normal haematological tests, chest X-ray, and echocardiography. The EGC presented first-degree AV block, right bundle branch block, and left anterior fascicular block. A dual-chamber pacemaker (PM) with ventricular lead in the right ventricle (RV) apex was then implanted without procedural complications. On the night following the implant, the patient complained of repeated self-limited episodes of interscapular pain with mild dyspnoea. The day after the ECG showed sinus rhythm triggering PM ventricular stimulation with ST segment elevation in inferior and anterior leads. PM inhibition showed the preexisting intraventricular conduction disturbance with inferior and anterior ST segment elevation (Figure 1). Chest X-ray excluded pneumothorax. At echocardiogram, akinesia of the apical portions of the LV with reduced LV systolic function was observed. Cardiac biomarkers were slightly increased. The patient was treated with intravenous nitrates and antithrombotic agents due to suspicion of AMI. For the persistence of symptoms and ECG alterations, coronary angiography was performed with no evidence of significant coronary lesion or spasm. The ventriculography revealed ballooning of apical region with typical so-called takotsubo shape (Figure 2). In the following days, reduction in ST segment elevation and transient negative T wave were observed at ECG. At predischarge echocardiography, LV systolic function improved, and wall motion abnormalities disappeared. The patient was discharged asymptomatic with normal cardiac enzymes, effective dual-chamber stimulation, and normalized systolic LV function.

Figure 1.

Evolving ECG aspect: (a) spontaneous sinus rhythm with first-degree AV block and right bundle branch block, (b) early postimplant with dual-chamber pacing, (c) dual-chamber pacing with ST segment elevation in inferior and anterior leads, (d) spontaneous rhythm with PM inhibited and ST segment elevation in inferior and anterior leads, and (e) dual-chamber pacing at discharge with evolving repolarization abnormalities.

Figure 2.

Ventriculography showing typical takotsubo-like shape of LV.

3. Discussion

The ABS is also known as takotsubo cardiomyopathy because the LV shape in the acute phase is very similar to a pot with round bottom and narrow neck used in Japan to trap octopuses [1, 4]. It is often preceded by emotional or physical stressful events. The underlying mechanism is unclear, but it seems mainly related to an excess of catecholamine release [3]. Pacemaker implantation even if uncomplicated may be sufficiently stressful in individual patients to precipitate this syndrome as previously described in some cases [5–10]. In our patient, as in the previously reported cases, no other perioperative stressful events other than implantation itself were identified that could explain the clinical syndrome, typically characterized by chest pain, ST segment elevation on ECG, transient LV wall motion abnormalities with takotsubo-like shape at ventriculography, slight cardiac enzymes increase, and absence of significant coronary lesions, according to current accepted criteria [2, 4]. The most common ECG presentation of ABS is ST segment elevation in precordial leads suggesting anterior wall AMI. Concomitant ST segment elevation or absence of ST segment depression in inferior leads has been proposed as an adjunctive ECG abnormality distinguishing ABS [11]. It is also interesting to note that acute myocardial ischemia may be difficult to identify based on ECG analysis in PM patients paced in the apex of the RV. Several signs were proposed, but they are all insensitive [12]. Marked ST segment elevation in predominantly negative QRS complex was proposed as a distinctive criterion [13], but this abnormality may be observed during classical apical RV pacing also in the absence of acute myocardial ischemia or infarction. Indeed, in symptomatic patients, the diagnosis should be based on new development of ST elevation [12]. In our patient, ST segment elevation in anterior and inferior leads was observed both during spontaneous AV conduction and during apical RV stimulation. The relevance of the latter finding in the diagnosis of ABS during apical RV pacing needs further evaluation. Moreover, a confusing factor inducing transient repolarization modifications in patients with modern dual-chamber PM may be the presence of variable AV delay and consequent variable degree of ventricular capture [14]. This may be observed in PM provided with algorithms aimed at prolonging the AV delay searching for spontaneous AV conduction or, on the contrary, aimed at decreasing the AV delay in response to increasing heart rate.

In conclusion, ABS should be suspected after pacemaker implantation in patients, especially postmenopausal women, presenting with angina-like symptoms and/or dyspnoea, new development of ST modification, and LV systolic dysfunction. The recovery of a preevent ECG aspect and of a normal LV systolic function in the followup may help to confirm the diagnosis.