Table 3 is incorrect. The authors have provided the correct version of Table 3 here.
Table 3. Significantly enriched gene pathways from Ingenuity Pathway Analysis.
| Top pathways | p-value | # of changed genes | |
| Diseases and disorders | Neurological diseases | 1.29E-05 | 591 |
| Cancer | 3.76E-05 | 455 | |
| Developmental disorder | 4.21E-05 | 500 | |
| Cardiovascular disease | 5.59E-05 | 440 | |
| Nutritional disease | 9.32E-05 | 182 | |
| Physiological development | Organismal development | 3.53E-06 | 993 |
| Organismal survival | 4.73E-06 | 621 | |
| Embryonic development | 3.47E-05 | 632 | |
| Organ development | 3.47E-05 | 557 | |
| Skeletal and muscular system development and function | 3.47E-05 | 393 | |
| Top toxicity lists | Cardiac hypertrophy | 6.41E-05 | 114/323 |
| Renal necrosis/cell death | 3.56E-04 | 128/383 | |
| Cardiac fibrosis | 4.71E-03 | 58/166 | |
| Mechanism of gene regulation by peroxisome proliferators via PPARa | 1.02E-02 | 35/95 | |
| Liver proliferation | 2.38E-02 | 61/189 | |
| Cardiotoxicity | Cardiac hypertrophy | 5.59E-05 | 115 |
| Pulmonary hypertension | 6.60E-04 | 22 | |
| Cardiac fibrosis | 2.43E-03 | 58 | |
| Cardiac arrhythmia | 1.44E-02 | 53 | |
| Cardiac output | 1.97E-02 | 15 |
Reference
- 1. Buscariollo DL, Fang X, Greenwood V, Xue H, Rivkees SA, et al. (2014) Embryonic Caffeine Exposure Acts via A1 Adenosine Receptors to Alter Adult Cardiac Function and DNA Methylation in Mice. PLoS ONE 9(1): e87547 doi:10.1371/journal.pone.0087547 [DOI] [PMC free article] [PubMed] [Google Scholar]