Figure 5. Correlation between human platelet aggregation and expression levels of human TBM or EPCR on GTKO/CD46 pAEC.
There was a significant correlation between human platelet aggregation after exposure to (A) GTKO/CD46/TBM (n=4) or (B) GTKO/CD46/EPCR (n=5) pAEC and the expression levels of human TBM or EPCR on the pAEC (both p<0.01). The pigs transgenic for TBM were from two different lines (high- and low-expressing), whereas those transgenic for EPCR were from a single line.