1-Methyl-3-phenyl­thio­urea

Abstract

The title compound, C₈H₁₀N₂S, was prepared by reaction of methyl­amine solution, KOH and phenyl-iso­thio­cyanate in ethanol. It adopts a syn-Me and anti-Ph conformation relative to the C=S double bond. The dihedral angle between the N—C(=S)—N thio­urea and phenyl planes is 67.83 (6)°. In the crystal, the mol­ecules centrosymmetrical dimers by pairs of N(Ph)—H⋯S hydrogen bonds. The dimers are linked by N(Me)—H⋯S hydrogen bonds into layers parallel to (100).

Related literature  

For applications of thio­urea derivatives, see: Madan & Taneja (1991 ▶); Xu et al. (2004 ▶); Borisova et al. (2007 ▶). For the crystal structures of related compounds, see: Ji et al. (2002 ▶); Wenzel et al. (2011 ▶).

Experimental  

Crystal data  

• C₈H₁₀N₂S

• M _r = 166.24

• Monoclinic,

• a = 17.348 (3) Å

• b = 8.6023 (13) Å

• c = 12.1672 (18) Å

• β = 99.637 (3)°

• V = 1790.1 (5) ų

• Z = 8

• Mo Kα radiation

• μ = 0.30 mm⁻¹

• T = 296 K

• 0.25 × 0.23 × 0.20 mm

Data collection  

• Bruker SMART CCD area-detector diffractometer

• 5444 measured reflections

• 2026 independent reflections

• 1424 reflections with I > 2σ(I)

• R _int = 0.033

Refinement  

• R[F ² > 2σ(F ²)] = 0.041

• wR(F ²) = 0.114

• S = 1.03

• 2026 reflections

• 109 parameters

• H atoms treated by a mixture of independent and constrained refinement

• Δρ_max = 0.24 e Å⁻³

• Δρ_min = −0.24 e Å⁻³

Data collection: SMART (Bruker 1997 ▶); cell refinement: SAINT (Bruker 1997 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS2013 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL2013 (Sheldrick, 2008 ▶); molecular graphics: SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXTL.

Supplementary Material

CCDC reference: 995308

Additional supporting information: crystallographic information; 3D view; checkCIF report

Table 1. Hydrogen-bond geometry (Å, °).

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1⋯S1i	0.81 (2)	2.55 (2)	3.351 (2)	169 (2)
N2—H2⋯S1ii	0.77 (2)	2.78 (2)	3.4229 (19)	142 (2)

Symmetry codes: (i) ; (ii) .

supplementary crystallographic information

1. Comment

Thioureas have been studied for many years because of their broad antibiosis and sterilibzation properties. Recent years study shows that thioureas not only can be used to kill insects and adjust plant growth but also have anti-viral activities (Madan & Taneja, 1991; Borisova et al., 2007). From our early quantum study on these compounds we find that they have several active centers and cart form polyligand complexes with metals easily (Xu et al., 2004). These complexes are widely used as anti-medicines. Therefore study on thioureas has important impact on the future. In order to search for new compounds with higher bioactivity, the title compound was synthesized.

In the title compound, C₈H₁₀N₂S (I), the bond lengths and angles are in a good agreement with those found in the related compounds (Ji et al., 2002; Wenzel et al. 2011). Compound I adopts a cis-Me and trans-Ph conformation relative to the C═S double bond (Figure 1). The dihedral angle between the N1—C7(═S1)—N1 thiourea and phenyl planes is 67.83 (6)°.

In the crystal, the molecules of I form centrosymmetrical dimers by the two intermolecular N1—H1···S1ⁱ hydrogen bonds (Table 1, Figure 2). The dimers are further bound to each other by the intermolecular N2—H2···S1ⁱⁱ hydrogen bonds (Table 1) into layers parallel to (100) (Figure 2). Symmetry codes: (i) –x + 1/2, –y + 5/2, –z + 1; (ii) –x + 1/2, y–1/2, –z + 1/2.

2. Experimental

The title compound was prepared by reaction of methylamine solution (40%, 0.05 mol, 5.5 ml), KOH (0.15 mol, 8.4 g) and phenyl-isothiocyanate(0.05 mol, 4.65 g) in the ethanol solution (40 ml) at room temperature. Single-crystals of the title compound suitable for X-ray measurements was obtained by recrystallization from ethanol/acetone (v/v=1:1) at room temperature.

3. Refinement

The hydrogen atoms of the amino groups were localized in the difference Fourier map and refined isotropically. The other hydrogen atoms were placed in the calculated positions with C—H = 0.93 Å (aryl–H) and 0.96 Å (methyl–H) and refined in the riding model with fixed isotropic displacement parameters: U_iso(H) = 1.5U_eq(C) for the CH₃ group and 1.2U_eq(C) for the other CH groups.

Figures

Fig. 1.

Molecular structure of I. Displacement ellipsoids are presented at the 40% probability level. H atoms are depicted as small spheres of arbitrary radius.

Fig. 2.

A portion of the crystal structure of I demonstrating the H–bonded dimers and layers parallel to (100). The hydrogen atoms participating in the formation of hydrogen bonds are shown only. The intermolecular N—H···S hydrogen bonds are depicted by dashed lines.

Crystal data

C8H10N2S	F(000) = 704
Mr = 166.24	Dx = 1.234 Mg m−3
Monoclinic, C2/c	Mo Kα radiation, λ = 0.71073 Å
a = 17.348 (3) Å	Cell parameters from 1286 reflections
b = 8.6023 (13) Å	θ = 2.4–24.8°
c = 12.1672 (18) Å	µ = 0.30 mm−1
β = 99.637 (3)°	T = 296 K
V = 1790.1 (5) Å3	Bar, colorless
Z = 8	0.25 × 0.23 × 0.20 mm

Data collection

Bruker SMART CCD area-detector diffractometer	Rint = 0.033
Radiation source: sealed tube	θmax = 27.5°, θmin = 2.4°
phi and ω scans	h = −22→21
5444 measured reflections	k = −8→11
2026 independent reflections	l = −15→15
1424 reflections with I > 2σ(I)

Refinement

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.041	Hydrogen site location: difference Fourier map
wR(F2) = 0.114	H atoms treated by a mixture of independent and constrained refinement
S = 1.03	w = 1/[σ2(Fo2) + (0.0587P)2 + 0.1272P] where P = (Fo2 + 2Fc2)/3
2026 reflections	(Δ/σ)max < 0.001
109 parameters	Δρmax = 0.24 e Å−3
0 restraints	Δρmin = −0.24 e Å−3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
S1	0.16423 (3)	1.19173 (6)	0.35515 (4)	0.04468 (19)
N1	0.29456 (9)	1.0463 (2)	0.43958 (15)	0.0467 (5)
N2	0.23002 (10)	0.9493 (2)	0.27416 (15)	0.0485 (5)
C1	0.35645 (10)	0.9351 (2)	0.45446 (17)	0.0401 (5)
C2	0.36233 (13)	0.8311 (3)	0.5403 (2)	0.0648 (7)
H2A	0.3251	0.8303	0.5871	0.078*
C3	0.42442 (15)	0.7264 (3)	0.5572 (3)	0.0814 (9)
H3	0.4287	0.6555	0.6156	0.098*
C4	0.47899 (13)	0.7275 (3)	0.4884 (3)	0.0683 (7)
H4	0.5202	0.6569	0.4997	0.082*
C5	0.47334 (12)	0.8309 (3)	0.4037 (2)	0.0646 (7)
H5	0.5109	0.8317	0.3573	0.077*
C6	0.41193 (11)	0.9357 (3)	0.38576 (18)	0.0510 (5)
H6	0.4082	1.0064	0.3273	0.061*
C7	0.23382 (9)	1.0531 (2)	0.35543 (15)	0.0353 (4)
C8	0.16755 (12)	0.9440 (3)	0.1781 (2)	0.0685 (7)
H8A	0.1740	1.0278	0.1284	0.103*
H8B	0.1180	0.9540	0.2026	0.103*
H8C	0.1695	0.8467	0.1401	0.103*
H1	0.2993 (12)	1.117 (3)	0.4843 (19)	0.054 (7)*
H2	0.2646 (12)	0.893 (3)	0.2769 (18)	0.052 (7)*

Atomic displacement parameters (Ų)

	U11	U22	U33	U12	U13	U23
S1	0.0346 (3)	0.0467 (3)	0.0524 (3)	0.0114 (2)	0.0062 (2)	0.0000 (2)
N1	0.0401 (9)	0.0497 (11)	0.0462 (11)	0.0157 (8)	−0.0043 (8)	−0.0147 (9)
N2	0.0365 (9)	0.0573 (12)	0.0482 (11)	0.0134 (8)	−0.0034 (8)	−0.0132 (9)
C1	0.0293 (8)	0.0418 (11)	0.0457 (11)	0.0061 (8)	−0.0044 (8)	−0.0085 (9)
C2	0.0512 (13)	0.0680 (17)	0.0758 (17)	0.0096 (11)	0.0123 (12)	0.0206 (13)
C3	0.0690 (17)	0.0612 (18)	0.109 (2)	0.0133 (14)	0.0015 (16)	0.0307 (16)
C4	0.0427 (12)	0.0587 (16)	0.097 (2)	0.0177 (11)	−0.0081 (13)	−0.0096 (15)
C5	0.0364 (10)	0.090 (2)	0.0637 (16)	0.0163 (11)	−0.0007 (10)	−0.0205 (14)
C6	0.0397 (10)	0.0647 (15)	0.0465 (12)	0.0101 (10)	0.0009 (9)	−0.0033 (11)
C7	0.0298 (9)	0.0394 (11)	0.0373 (10)	0.0024 (7)	0.0075 (8)	0.0004 (9)
C8	0.0504 (12)	0.093 (2)	0.0555 (14)	0.0138 (12)	−0.0108 (11)	−0.0244 (14)

Geometric parameters (Å, º)

S1—C7	1.6964 (17)	C3—C4	1.365 (4)
N1—C7	1.342 (2)	C3—H3	0.9300
N1—C1	1.427 (2)	C4—C5	1.353 (4)
N1—H1	0.81 (2)	C4—H4	0.9300
N2—C7	1.326 (2)	C5—C6	1.384 (3)
N2—C8	1.455 (3)	C5—H5	0.9300
N2—H2	0.77 (2)	C6—H6	0.9300
C1—C2	1.366 (3)	C8—H8A	0.9600
C1—C6	1.376 (3)	C8—H8B	0.9600
C2—C3	1.393 (3)	C8—H8C	0.9600
C2—H2A	0.9300
C7—N1—C1	127.17 (17)	C3—C4—H4	119.9
C7—N1—H1	117.4 (16)	C4—C5—C6	120.2 (2)
C1—N1—H1	115.2 (16)	C4—C5—H5	119.9
C7—N2—C8	123.87 (18)	C6—C5—H5	119.9
C7—N2—H2	117.0 (17)	C1—C6—C5	120.0 (2)
C8—N2—H2	119.0 (17)	C1—C6—H6	120.0
C2—C1—C6	119.74 (18)	C5—C6—H6	120.0
C2—C1—N1	119.64 (18)	N2—C7—N1	118.32 (17)
C6—C1—N1	120.57 (18)	N2—C7—S1	121.70 (15)
C1—C2—C3	119.6 (2)	N1—C7—S1	119.98 (14)
C1—C2—H2A	120.2	N2—C8—H8A	109.5
C3—C2—H2A	120.2	N2—C8—H8B	109.5
C4—C3—C2	120.2 (3)	H8A—C8—H8B	109.5
C4—C3—H3	119.9	N2—C8—H8C	109.5
C2—C3—H3	119.9	H8A—C8—H8C	109.5
C5—C4—C3	120.2 (2)	H8B—C8—H8C	109.5
C5—C4—H4	119.9
C7—N1—C1—C2	−112.2 (2)	C2—C1—C6—C5	0.1 (3)
C7—N1—C1—C6	70.3 (3)	N1—C1—C6—C5	177.57 (19)
C6—C1—C2—C3	−0.1 (3)	C4—C5—C6—C1	0.2 (3)
N1—C1—C2—C3	−177.7 (2)	C8—N2—C7—N1	−179.8 (2)
C1—C2—C3—C4	−0.1 (4)	C8—N2—C7—S1	0.4 (3)
C2—C3—C4—C5	0.4 (4)	C1—N1—C7—N2	−1.9 (3)
C3—C4—C5—C6	−0.4 (4)	C1—N1—C7—S1	177.91 (16)

Hydrogen-bond geometry (Å, º)

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1···S1i	0.81 (2)	2.55 (2)	3.351 (2)	169 (2)
N2—H2···S1ii	0.77 (2)	2.78 (2)	3.4229 (19)	142 (2)

Symmetry codes: (i) −x+1/2, −y+5/2, −z+1; (ii) −x+1/2, y−1/2, −z+1/2.