Figure 3. The repression domain and interaction motif are both essential for maximal repression of the AR.
COS-1 cells were transiently transfected with vectors for the AR, TAT-GRE-E1B-LUC, PDM-LACZ-β-GAL and MAD7-35-AR1-54 with wild-type or mutated (a) interaction motif (FQNLF to FQNAA) or (b) repression domain (L12P and A16P). Mean ±1SE. T-Test - ** p<0.005, *** p<0.0005.