Table 3.
—Demographics, Clinical Characteristics, and Outcomes of Patients With P aeruginosa CAP by Admission to the ICU
| No ICU (n = 266) | ICU (n = 136) | |||||
| Characteristic or Outcome | Nonmacrolide (n = 156) | Macrolide (n = 110) | P Value | Nonmacrolide (n = 75) | Macrolide (n = 61) | P Value |
| Age, y | 76.2 ± 6.4 | 78.2 ± 6.3 | .01 | 75.8 ± 6.8 | 76.0 ± 5.3 | .8 |
| Male sex | 154 (98.7) | 110 (100) | .2 | 73 (97.3) | 61 (100) | .1 |
| Married | 84 (53.8) | 57 (51.8) | .7 | 33 (44.0) | 36 (59.0) | .08 |
| Race | ||||||
| White | 131 (84.0) | 98 (89.1) | .2 | 55 (73.3) | 54 (88.5) | .02 |
| Black | 9 (5.8) | 6 (5.5) | .9 | 10 (13.3) | 5 (8.2) | .3 |
| Smoker | 64 (41.0) | 46 (41.8) | .8 | 25 (33.3) | 23 (37.7) | .5 |
| Alcohol abuse | 8 (5.1) | 4 (3.6) | .5 | 3 (4.0) | 3 (4.9) | .7 |
| Comorbid conditions | ||||||
| Myocardial infarction | 4 (2.6) | 5 (4.5) | .3 | 3 (4.0) | 0 | .1 |
| Chronic heart failure | 25 (16.0) | 21 (19.1) | .5 | 10 (13.3) | 13 (21.3) | .2 |
| Peripheral vascular disease | 19 (12.2) | 11 (10.0) | .5 | 10 (13.3) | 8 (13.1) | .9 |
| Cerebrovascular disease | 22 (14.1) | 9 (8.2) | .1 | 13 (17.3) | 12 (19.7) | .7 |
| Dementia | 4 (2.6) | 6 (5.5) | .2 | 3 (4.0) | 4 (6.6) | .5 |
| COPD | 124 (79.5) | 79 (71.8) | .1 | 36 (48.0) | 42 (68.9) | .01 |
| Diabetes mellitus | 29 (18.6) | 20 (18.2) | .9 | 21 (28.0) | 14 (23.0) | .5 |
| Diabetes with complications | 4 (2.6) | 6 (5.5) | .2 | 7 (9.3) | 8 (13.1) | .4 |
| Neoplastic disease | 26 (16.7) | 26 (23.6) | .1 | 19 (25.3) | 11 (18.0) | .3 |
| Metastatic disease | 4 (2.6) | 3 (2.7) | .9 | 3 (4.0) | 3 (4.9) | .7 |
| Charlson comorbidity index score | 76.2 ± 6.4 | 78.2 ± 6.3 | .5 | 2.3 ± 2.3 | 2.6 ± 2.3 | .4 |
| P aeruginosa antibiotic coverage | 146 (93.6) | 100 (90.9) | .4 | 59 (78.7) | 54 (88.5) | .1 |
| 30-d mortality | 17 (10.9) | 12 (10.9) | .9 | 21 (28.0) | 20 (32.8) | .5 |
| Use of mechanical ventilation | … | … | … | 58 (77.3) | 44 (72.1) | .4 |
| Use of vasopressors | … | … | … | 35 (46.7) | 26 (42.6) | .6 |
| LOS | 12.0 ± 16.5 | 10.8 ± 10.4 | .5 | 37.7 ± 48.7 | 33.6 ± 32.2 | .5 |