Table 1.
List of metabolite standards used to assess the analytical performance of chemical derivatization.
| Metabolite class | Metabolite representatives and abbreviations |
|---|---|
| Neutral amino acids | Alanine (ALA), valine (VAL), glutamine (GLN) |
| Basic amino acids | Lysine (LYS) |
| Acidic amino acids | Glutamate (GLU), aspartate (ASP) |
| Aromatic amino acids | Phenylalanine (PHE), tryptophan (TRP) |
| Sulfur-containing amino acids | Methionine (MET), cysteine (CYS) |
| Monocarboxylic acids | 2-Hydroxybutyrate (2HB), lactate (LAC), phosphoenolpyruvate (PEP) |
| Dicarboxylic acids | Succinate (SUC), fumarate (FUM), oxaloacetate (OAA) |
| Tricarboxylic acids | Citrate (CIT), isocitrate (ICI) |
| Aromatic carboxylic acids | p-Coumarate (COU), ferulate (FER) |
| 2-oxo-acids | 2-oxoglutarate (AKG), 3-methyl-2oxovalerate (OIVAL) |
| Fatty acids | Myristate (MYR), palmitate (PAL) |
| Nucleotides | NAD+, NADP+ |
| Internal standard | L-Alanine-2,3,3,3-d4 (D4-ALA) |