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. Author manuscript; available in PMC: 2014 May 8.
Published in final edited form as: Oncogene. 2010 Apr 26;29(26):3770–3780. doi: 10.1038/onc.2010.126

Figure 5.

Figure 5

Interaction between MIG-6 and ERK2 in the murine uterus. (A) Validation of the MIG-6 interaction with ERK2 by co-immunoprecipitation and Western blot analysis. (B) Western blot analysis of ERK2 and phospho-ERK2 in the uteri of 5 month old Mig-6f/f and Mig- 6d/d mice. (C) Western blot analysis of ERK2 and phospho-ERK2 in the uteri of 2 weeks old control, Mig-6d/d, Ptend/d, and Mig-6d/d Ptend/d mice. (D) The expression of ERK2 target genes. Real-time RT-PCR analysis of Fos, Junb, Ptgs2, Gdf15, Vegfa, F3, and Serpin1 was performed on uteri of control, Mig-6d/d, Ptend/d, and Mig-6d/d Ptend/d mice. **, p<0.01; ***, p<0.001