Skip to main content
NCBI home page
The EMBO Journal logoLink to The EMBO Journal
. 1989 Dec 1;8(12):3749–3757. doi: 10.1002/j.1460-2075.1989.tb08551.x

Genetic and molecular mapping of the Hmt region of mouse.

S Richards 1, M Bucan 1, K Brorson 1, M C Kiefer 1, S W Hunt 3rd 1, H Lehrach 1, K F Lindahl 1
PMCID: PMC402060  PMID: 2573520

Abstract

We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

Full text

PDF
3749

Images in this article

3750Image
on p.3750
3750Image
on p.3750
3752Image
on p.3752
3752Image
on p.3752
3753Image
on p.3753
3753Image
on p.3753

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blin N., Stafford D. W. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 1976 Sep;3(9):2303–2308. doi: 10.1093/nar/3.9.2303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boer P. H., Adra C. N., Lau Y. F., McBurney M. W. The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. Mol Cell Biol. 1987 Sep;7(9):3107–3112. doi: 10.1128/mcb.7.9.3107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown G. D., Choi Y., Egan G., Meruelo D. Extension of the H-2 TLb molecular map. Isolation and characterization of T13, T14, and T15 from the C57BL/6 mouse. Immunogenetics. 1988;27(4):239–251. doi: 10.1007/BF00376118. [DOI] [PubMed] [Google Scholar]
  4. Búcan M., Herrmann B. G., Frischauf A. M., Bautch V. L., Bode V., Silver L. M., Martin G. R., Lehrach H. Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Genes Dev. 1987 Jun;1(4):376–385. doi: 10.1101/gad.1.4.376. [DOI] [PubMed] [Google Scholar]
  5. Chan T., Fischer Lindahl K. Skin graft rejection caused by the maternally transmitted antigen Mta. Transplantation. 1985 May;39(5):477–480. doi: 10.1097/00007890-198505000-00003. [DOI] [PubMed] [Google Scholar]
  6. Feinberg A. P., Vogelstein B. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem. 1984 Feb;137(1):266–267. doi: 10.1016/0003-2697(84)90381-6. [DOI] [PubMed] [Google Scholar]
  7. Ferris S. D., Ritte U., Lindahl K. F., Prager E. M., Wilson A. C. Unusual type of mitochondrial DNA in mice lacking a maternally transmitted antigen. Nucleic Acids Res. 1983 May 11;11(9):2917–2926. doi: 10.1093/nar/11.9.2917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fisher D. A., Hunt S. W., 3rd, Hood L. Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse. J Exp Med. 1985 Aug 1;162(2):528–545. doi: 10.1084/jem.162.2.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Han A. C., Rodgers J. R., Rich R. R. Unglycosylated Mtaa expresses an Mtab-like determinant. Immunogenetics. 1987;25(4):234–240. doi: 10.1007/BF00404693. [DOI] [PubMed] [Google Scholar]
  10. Huston M. M., Smith R., 3rd, Hull R., Huston D. P., Rich R. R. Mitochondrial modulation of maternally transmitted antigen: analysis of cell hybrids. Proc Natl Acad Sci U S A. 1985 May;82(10):3286–3290. doi: 10.1073/pnas.82.10.3286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kasahara M., Figueroa F., Klein J. Random cloning of genes from mouse chromosome 17. Proc Natl Acad Sci U S A. 1987 May;84(10):3325–3328. doi: 10.1073/pnas.84.10.3325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kasahara M., Passmore H. C., Klein J. A testis-specific gene Tpx-1 maps between Pgk-2 and Mep-1 on mouse chromosome 17. Immunogenetics. 1989;29(1):61–63. doi: 10.1007/BF02341616. [DOI] [PubMed] [Google Scholar]
  13. Klein D., Tewarson S., Figueroa F., Klein J. The minimal length of the differential segment in H-2 congenic lines. Immunogenetics. 1982;16(4):319–328. doi: 10.1007/BF00372303. [DOI] [PubMed] [Google Scholar]
  14. Lalanne J. L., Transy C., Guerin S., Darche S., Meulien P., Kourilsky P. Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver. Cell. 1985 Jun;41(2):469–478. doi: 10.1016/s0092-8674(85)80020-9. [DOI] [PubMed] [Google Scholar]
  15. Lindahl K. F., Bürki K. Mta, a maternally inherited cell surface antigen of the mouse, is transmitted in the egg. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5362–5366. doi: 10.1073/pnas.79.17.5362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lindahl K. F., Hausmann B., Chapman V. M. A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983 Nov 24;306(5941):383–385. doi: 10.1038/306383a0. [DOI] [PubMed] [Google Scholar]
  17. Lindahl K. F., Hausmann B. Cytoplasmic inheritance of a cell surface antigen in the mouse. Genetics. 1983 Mar;103(3):483–494. doi: 10.1093/genetics/103.3.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lindahl K. F., Hausmann B., Robinson P. J., Guénet J. L., Wharton D. C., Winking H. Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes. J Exp Med. 1986 Feb 1;163(2):334–346. doi: 10.1084/jem.163.2.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lindahl K. F., Langhorne J. Medial histocompatibility antigens. Scand J Immunol. 1981 Dec;14(6):643–654. doi: 10.1111/j.1365-3083.1981.tb00607.x. [DOI] [PubMed] [Google Scholar]
  20. Moore K. W., Sher B. T., Sun Y. H., Eakle K. A., Hood L. DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen. Science. 1982 Feb 5;215(4533):679–682. doi: 10.1126/science.7058332. [DOI] [PubMed] [Google Scholar]
  21. Nadeau J. H. Absence of detectable gametic disequilibrium between the t-complex and linked allozyme-encoding loci in house mice. Genet Res. 1983 Dec;42(3):323–333. doi: 10.1017/s0016672300021807. [DOI] [PubMed] [Google Scholar]
  22. Reckelhoff J. F., Butler P. E., Bond J. S., Beynon R. J., Passmore H. C. Mep-1, the gene regulating meprin activity, maps between Pgk-2 and Ce-2 on mouse chromosome 17. Immunogenetics. 1988;27(4):298–300. doi: 10.1007/BF00376127. [DOI] [PubMed] [Google Scholar]
  23. Rodgers J. R., Smith R., 3rd, Huston M. M., Rich R. R. Maternally transmitted antigen. Adv Immunol. 1986;38:313–359. doi: 10.1016/s0065-2776(08)60010-3. [DOI] [PubMed] [Google Scholar]
  24. Röhme D., Fox H., Herrmann B., Frischauf A. M., Edström J. E., Mains P., Silver L. M., Lehrach H. Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Cell. 1984 Mar;36(3):783–788. doi: 10.1016/0092-8674(84)90358-1. [DOI] [PubMed] [Google Scholar]
  25. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Singer D. S., Hare J., Golding H., Flaherty L., Rudikoff S. Characterization of a new subfamily of class I genes in the H-2 complex of the mouse. Immunogenetics. 1988;28(1):13–21. doi: 10.1007/BF00372524. [DOI] [PubMed] [Google Scholar]
  27. Smith R., 3rd, Huston M. M., Jenkins R. N., Huston D. P., Rich R. R. Mitochondria control expression of a murine cell surface antigen. Nature. 1983 Dec 8;306(5943):599–601. doi: 10.1038/306599a0. [DOI] [PubMed] [Google Scholar]
  28. Steinmetz M., Frelinger J. G., Fisher D., Hunkapiller T., Pereira D., Weissman S. M., Uehara H., Nathenson S., Hood L. Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell. 1981 Apr;24(1):125–134. doi: 10.1016/0092-8674(81)90508-0. [DOI] [PubMed] [Google Scholar]
  29. Steinmetz M., Moore K. W., Frelinger J. G., Sher B. T., Shen F. W., Boyse E. A., Hood L. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell. 1981 Sep;25(3):683–692. doi: 10.1016/0092-8674(81)90175-6. [DOI] [PubMed] [Google Scholar]
  30. Steinmetz M., Stephan D., Fischer Lindahl K. Gene organization and recombinational hotspots in the murine major histocompatibility complex. Cell. 1986 Mar 28;44(6):895–904. doi: 10.1016/0092-8674(86)90012-7. [DOI] [PubMed] [Google Scholar]
  31. Steinmetz M., Winoto A., Minard K., Hood L. Clusters of genes encoding mouse transplantation antigens. Cell. 1982 Mar;28(3):489–498. doi: 10.1016/0092-8674(82)90203-3. [DOI] [PubMed] [Google Scholar]
  32. Szymura J. M., Klein J. Linkage of a gene controlling urinary pepsinogen with the major histocompatibility complex of the mouse. Immunogenetics. 1981;13(3):267–271. doi: 10.1007/BF00350793. [DOI] [PubMed] [Google Scholar]
  33. Transy C., Nash S. R., David-Watine B., Cochet M., Hunt S. W., 3rd, Hood L. E., Kourilsky P. A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types. J Exp Med. 1987 Aug 1;166(2):341–361. doi: 10.1084/jem.166.2.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Weiss E. H., Golden L., Fahrner K., Mellor A. L., Devlin J. J., Bullman H., Tiddens H., Bud H., Flavell R. A. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature. 1984 Aug 23;310(5979):650–655. doi: 10.1038/310650a0. [DOI] [PubMed] [Google Scholar]
  35. Winoto A., Steinmetz M., Hood L. Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex. Proc Natl Acad Sci U S A. 1983 Jun;80(11):3425–3429. doi: 10.1073/pnas.80.11.3425. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The EMBO Journal are provided here courtesy of Nature Publishing Group

RESOURCES