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. 1992 Jul 1;89(13):6006–6009. doi: 10.1073/pnas.89.13.6006

Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate.

H Matsue 1, K G Rothberg 1, A Takashima 1, B A Kamen 1, R G Anderson 1, S W Lacey 1
PMCID: PMC402127  PMID: 1631087

Abstract

The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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