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. 2013 Jul 11;4(8):569–572. doi: 10.1007/s13238-013-3903-2

The sequence signature of an Ig-fold

Jia-Huai Wang 13903,23903,✉
PMCID: PMC4022342  NIHMSID: NIHMS582017  PMID: 23842991

Abstract

Ig superfamily (IgSF) constitutes the largest superfamily in human genome. In particular, Ig-like domains are the most abundant structural module within cell surface receptors, functioning in nervous as well as immune system. Here I describe some key sequence signature of an I-set Ig-like domain from known structures of IgSF members. These signature residues define the I-set Ig-like domain, which should aid structural and functional studies of cell surface receptors.

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