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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1996 Jan 9;93(1):290–294. doi: 10.1073/pnas.93.1.290

Reversible visual hemineglect.

B R Payne 1, S G Lomber 1, S Geeraerts 1, E van der Gucht 1, E Vandenbussche 1
PMCID: PMC40224  PMID: 8552624

Abstract

We have identified a limited region in the posterior, but not anterior, half of the cat's middle suprasylvian region which, when cooled and inactivated unilaterally, results in a profound visual neglect of stimuli introduced into the contracooled hemifield. The severity of the deficit matches that induced by unilateral cooling of the superior colliculus. The cortical region is located at the temporo-occipito-parietal junction and is believed to be equivalent to a region centered on or close to the area V5 complex of primates.

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Selected References

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  1. Boussaoud D., Joseph J. P. Role of the cat substantia nigra pars reticulata in eye and head movements. II. Effects of local pharmacological injections. Exp Brain Res. 1985;57(2):297–304. doi: 10.1007/BF00236535. [DOI] [PubMed] [Google Scholar]
  2. Hardy S. C., Stein B. E. Small lateral suprasylvian cortex lesions produce visual neglect and decreased visual activity in the superior colliculus. J Comp Neurol. 1988 Jul 22;273(4):527–542. doi: 10.1002/cne.902730408. [DOI] [PubMed] [Google Scholar]
  3. Harting J. K., Huerta M. F., Hashikawa T., Weber J. T., Van Lieshout D. P. Neuroanatomical studies of the nigrotectal projection in the cat. J Comp Neurol. 1988 Dec 22;278(4):615–631. doi: 10.1002/cne.902780412. [DOI] [PubMed] [Google Scholar]
  4. Harting J. K., Updyke B. V., Van Lieshout D. P. Corticotectal projections in the cat: anterograde transport studies of twenty-five cortical areas. J Comp Neurol. 1992 Oct 15;324(3):379–414. doi: 10.1002/cne.903240308. [DOI] [PubMed] [Google Scholar]
  5. Harting J. K., Van Lieshout D. P. Spatial relationships of axons arising from the substantia nigra, spinal trigeminal nucleus, and pedunculopontine tegmental nucleus within the intermediate gray of the cat superior colliculus. J Comp Neurol. 1991 Mar 22;305(4):543–558. doi: 10.1002/cne.903050403. [DOI] [PubMed] [Google Scholar]
  6. Hikosaka O., Wurtz R. H. Modification of saccadic eye movements by GABA-related substances. II. Effects of muscimol in monkey substantia nigra pars reticulata. J Neurophysiol. 1985 Jan;53(1):292–308. doi: 10.1152/jn.1985.53.1.292. [DOI] [PubMed] [Google Scholar]
  7. Hikosaka O., Wurtz R. H. Visual and oculomotor functions of monkey substantia nigra pars reticulata. I. Relation of visual and auditory responses to saccades. J Neurophysiol. 1983 May;49(5):1230–1253. doi: 10.1152/jn.1983.49.5.1230. [DOI] [PubMed] [Google Scholar]
  8. Hyvärinen J. Posterior parietal lobe of the primate brain. Physiol Rev. 1982 Jul;62(3):1060–1129. doi: 10.1152/physrev.1982.62.3.1060. [DOI] [PubMed] [Google Scholar]
  9. Joseph J. P., Boussaoud D. Role of the cat substantia nigra pars reticulata in eye and head movements. I. Neural activity. Exp Brain Res. 1985;57(2):286–296. doi: 10.1007/BF00236534. [DOI] [PubMed] [Google Scholar]
  10. Joseph J. P., Giroud P. Visuomotor properties of neurons of the anterior suprasylvian gyrus in the awake cat. Exp Brain Res. 1986;62(2):355–362. doi: 10.1007/BF00238855. [DOI] [PubMed] [Google Scholar]
  11. Lomber S. G., Cornwell P., Sun J. S., MacNeil M. A., Payne B. R. Reversible inactivation of visual processing operations in middle suprasylvian cortex of the behaving cat. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2999–3003. doi: 10.1073/pnas.91.8.2999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lynch J. C., McLaren J. W. Deficits of visual attention and saccadic eye movements after lesions of parietooccipital cortex in monkeys. J Neurophysiol. 1989 Jan;61(1):74–90. doi: 10.1152/jn.1989.61.1.74. [DOI] [PubMed] [Google Scholar]
  13. Mesulam M. M. A cortical network for directed attention and unilateral neglect. Ann Neurol. 1981 Oct;10(4):309–325. doi: 10.1002/ana.410100402. [DOI] [PubMed] [Google Scholar]
  14. Payne B. R. Evidence for visual cortical area homologs in cat and macaque monkey. Cereb Cortex. 1993 Jan-Feb;3(1):1–25. doi: 10.1093/cercor/3.1.1. [DOI] [PubMed] [Google Scholar]
  15. Payne B. R. Representation of the ipsilateral visual field in the transition zone between areas 17 and 18 of the cat's cerebral cortex. Vis Neurosci. 1990 May;4(5):445–474. doi: 10.1017/s0952523800005204. [DOI] [PubMed] [Google Scholar]
  16. Rafal R. D. Neglect. Curr Opin Neurobiol. 1994 Apr;4(2):231–236. doi: 10.1016/0959-4388(94)90078-7. [DOI] [PubMed] [Google Scholar]
  17. Rizzolatti G., Berti A. Neglect as a neural representation deficit. Rev Neurol (Paris) 1990;146(10):626–634. [PubMed] [Google Scholar]
  18. Royce G. J., Laine E. J. Efferent connections of the caudate nucleus, including cortical projections of the striatum and other basal ganglia: an autoradiographic and horseradish peroxidase investigation in the cat. J Comp Neurol. 1984 Jun 10;226(1):28–49. doi: 10.1002/cne.902260104. [DOI] [PubMed] [Google Scholar]
  19. SPRAGUE J. M., MEIKLE T. H., Jr THE ROLE OF THE SUPERIOR COLLICULUS IN VISUALLY GUIDED BEHAVIOR. Exp Neurol. 1965 Jan;11:115–146. doi: 10.1016/0014-4886(65)90026-9. [DOI] [PubMed] [Google Scholar]
  20. Sherman S. M. The effect of superior colliculus lesions upon the visual fields of cats with cortical ablations. J Comp Neurol. 1977 Mar 15;172(2):211–229. doi: 10.1002/cne.901720203. [DOI] [PubMed] [Google Scholar]
  21. Shupert C., Cornwell P., Payne B. Differential sparing of depth perception, orienting, and optokinetic nystagmus after neonatal versus adult lesions of cortical areas 17, 18, and 19 in the cat. Behav Neurosci. 1993 Aug;107(4):633–650. doi: 10.1037//0735-7044.107.4.633. [DOI] [PubMed] [Google Scholar]
  22. Sprague J. M. Interaction of cortex and superior colliculus in mediation of visually guided behavior in the cat. Science. 1966 Sep 23;153(3743):1544–1547. doi: 10.1126/science.153.3743.1544. [DOI] [PubMed] [Google Scholar]
  23. Tootell R. B., Taylor J. B. Anatomical evidence for MT and additional cortical visual areas in humans. Cereb Cortex. 1995 Jan-Feb;5(1):39–55. doi: 10.1093/cercor/5.1.39. [DOI] [PubMed] [Google Scholar]
  24. Toyama K., Fujii K., Umetani K. Functional differentiation between the anterior and posterior Clare-Bishop cortex of the cat. Exp Brain Res. 1990;81(2):221–233. doi: 10.1007/BF00228111. [DOI] [PubMed] [Google Scholar]
  25. Updyke B. V. Organization of visual corticostriatal projections in the cat, with observations on visual projections to claustrum and amygdala. J Comp Neurol. 1993 Jan 8;327(2):159–193. doi: 10.1002/cne.903270202. [DOI] [PubMed] [Google Scholar]
  26. Wallace S. F., Rosenquist A. C., Sprague J. M. Ibotenic acid lesions of the lateral substantia nigra restore visual orientation behavior in the hemianopic cat. J Comp Neurol. 1990 Jun 8;296(2):222–252. doi: 10.1002/cne.902960204. [DOI] [PubMed] [Google Scholar]
  27. Watson J. D., Myers R., Frackowiak R. S., Hajnal J. V., Woods R. P., Mazziotta J. C., Shipp S., Zeki S. Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. Cereb Cortex. 1993 Mar-Apr;3(2):79–94. doi: 10.1093/cercor/3.2.79. [DOI] [PubMed] [Google Scholar]
  28. Watson R. T., Valenstein E., Day A., Heilman K. M. Posterior neocortical systems subserving awareness and neglect. Neglect associated with superior temporal sulcus but not area 7 lesions. Arch Neurol. 1994 Oct;51(10):1014–1021. doi: 10.1001/archneur.1994.00540220060015. [DOI] [PubMed] [Google Scholar]
  29. Yamasaki D. S., Wurtz R. H. Recovery of function after lesions in the superior temporal sulcus in the monkey. J Neurophysiol. 1991 Sep;66(3):651–673. doi: 10.1152/jn.1991.66.3.651. [DOI] [PubMed] [Google Scholar]
  30. Zeki S., Watson J. D., Lueck C. J., Friston K. J., Kennard C., Frackowiak R. S. A direct demonstration of functional specialization in human visual cortex. J Neurosci. 1991 Mar;11(3):641–649. doi: 10.1523/JNEUROSCI.11-03-00641.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]

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