Table 1. Demographic Characteristics of the 22 Data Sets Included in the Meta-Analysis.
|
Patients with OCD |
Comparison controls |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Age (mean) | Males | Right handed | Years of education | Age of onset | Duration of illness | YBOCS (mean) | Drug free (%) | Drug naive (%) | N | Age (mean) | Males | Right handed | Years of education | |
| White matter volume | |||||||||||||||
| Carmona et al (2007) | 18 | 12.9 | 72% | 83% | – | – | – | 21.4 | 44% | 44% | 18 | 13.0 | 72% | 83% | – |
| Duran et al (2009) | 19 | 32.7 | 53% | 89% | – | 14.4 | 18.3 | 24.6 | 42% | 16% | 15 | 32.3 | 47% | 73% | – |
| Koprivova et al (2009) | 14 | 28.6 | 36% | 100% | – | 13.9 | 15.6 | 16.4 | 29% | – | 15 | 28.7 | 40% | 100% | – |
| Lazaro et al (2011) | 27 | 15.6 | 56% | 100% | 9.8 | 13.0 | 2.4 | 16.7 | 0% | 0% | 27 | 16.1 | 48% | 100% | 10.3 |
| Matsumoto et al (2010) | 16 | 32.8 | 44% | 88% | – | – | – | 22.0 | 63% | 25% | 32 | 32.6 | 44% | 84% | – |
| Pujol et al (2004) | 72 | 29.8 | 56% | 85% | 13.2 | 17.0 | 13.0 | 26.7 | 25% | 7% | 72 | 30.1 | 56% | 85% | 14.0 |
| Riffkin et al (2005) | 18 | 36.1 | 44% | 94% | 12.1 | – | – | 23.3 | 78% | – | 18 | 34.5 | 44% | 94% | 13.4 |
| Togao et al (2010) | 23 | 32.6 | 39% | 91% | 14.0 | 19.3 | 12.9 | 29.8 | 100% | 22% | 26 | 31.3 | 46% | 92% | 14.9 |
| van den Heuvel et al (2009) | 55 | 33.7 | 29% | 89% | 15.3 | 14.4 | 18.7 | 22.8 | 100% | 44% | 50 | 31.4 | 40% | 90% | 16.2 |
| Yoo et al (2008) | 71 | 26.6 | 66% | 96% | 14.0 | 18.6 | 8.0 | 22.8 | 17% | 17% | 71 | 26.7 | 66% | 100% | 15.2 |
| Fractional anisotropy | |||||||||||||||
| Admon et al (2012) | 13 | 25.5 | 77% | 100% | 13.5 | – | 8 | 24.5 | 0% | 0% | 13 | 27.0 | 77% | 100% | 14.0 |
| Cannistraro et al (2001) | 8 | 26.4 | 38% | 100% | 15.6 | – | – | 22.9 | 100% | – | 10 | 23.3 | 40% | 100% | 15.9 |
| Fan et al (2012) | 27 | 25.5 | 63% | 100% | 14.0 | 20.4 | 4.8 | 22.0 | 100% | 48% | 23 | 28.8 | 65% | 100% | 14.6 |
| Garibotto et al (2010) | 15 | 31.9 | 100% | 100% | 13.9 | 20.7 | 10.13 | 28.2 | 13% | – | 16 | 29.7 | 100% | 100% | 17.6 |
| Gruner et al (2010) | 23 | 14.3 | 57% | 83% | – | – | – | 26.9 | 48% | 39% | 23 | 14.2 | 52% | 74% | – |
| Ha et al (2009) check | 12 | 22.3 | 100% | – | – | – | – | 22.5 | – | – | 25 | 23.7 | 100% | – | – |
| Ha et al (2009) clean | 10 | 24.5 | 100% | – | – | – | – | 20.2 | – | – | 25 | 23.7 | 100% | – | – |
| Li et al (2011) | 23 | 27.2 | 70% | 100% | 13.3 | 20.9 | 6.3 | 23.2 | 43% | 43% | 23 | 26.7 | 70% | 100% | 13.4 |
| Menzies et al (2008) | 30 | 32.2 | 30% | 87% | – | – | – | 22.1 | 23% | – | 30 | 33.7 | 33% | 77% | – |
| Nakamae et al (2008) | 15 | 29.7 | 60% | 93% | 15.2 | 19.6 | – | 29 | 0% | 0% | 15 | 29.1 | 60% | 93% | 15.7 |
| Szeszko et al (2005) | 15 | 38.5 | 67% | 60% | 14.8 | 16.9 | 21.6 | 25.9 | 20% | – | 15 | 38.5 | 67% | 60% | 15.9 |
| Yoo et al (2007) | 13 | 27.8 | 62% | 100% | 15.3 | 20.6 | 7.2 | 30.2 | 100% | 92% | 13 | 26.9 | 62% | 100% | 15.1 |
Check and clean indicate the subsample of patients in this study.