AUTHOR CORRECTION
Volume 50, no. 4, p 1376–1383, 2006. Page 1376: Abstract, line 18, should read “Mean free-drug %T>MICs ± the standard deviation associated with the static effect endpoint for S. pneumoniae, S. aureus, and gram-negative isolates were 39 ± 9, 26 ± 8, and 47 ± 8, respectively.”
Page 1380: Table 3 should appear as shown below, with corrected MIC values for the bottom third of the table.
TABLE 3.
PPP-0903 in vivo activity in murine thigh and lung infection models against multiple organisms
| Organism | MIC (mg/liter) | Static |
1 log kill |
2 log kill |
|||
|---|---|---|---|---|---|---|---|
| Dose (mg/kg/24 h) | %T>MIC | Dose (mg/kg/24 h) | %T>MIC | Dose (mg/kg/24 h) | %T>MIC | ||
| S. pneumoniae 10813 (neutropenic) | 0.008 | 0.32 | 34 | 0.45 | 37 | 0.61 | 43 |
| S. pneumoniae 10813 (normal) | 0.20 | 29 | 0.29 | 33 | 0.41 | 36 | |
| S. pneumoniae 1199 | 0.06 | 1.8 | 35 | 3.42 | 44 | 6.03 | 51 |
| S. pneumoniae 1329 | 0.06 | 1.15 | 30 | 2.04 | 37 | 3.72 | 45 |
| S. pneumoniae 1325 | 0.06 | 6.5 | 52 | 8.46 | 53 | 10.65 | 60 |
| S. pneumoniae 1293 | 0.12 | 14.3 | 50 | 22.2 | 59 | 34.0 | 64 |
| Mean ± SD | 39 ± 9 | 43 ± 9 | 50 ± 10 | ||||
| S. aureus 25923 | 0.12 | 3.75 | 36 | 7.23 | 44 | 14.8 | 51 |
| S. aureus 29213 | 0.25 | 2.57 | 30 | 7.63 | 37 | 26.9 | 56 |
| MRSA | 0.50 | 9.88 | 21 | 22.0 | 34 | 64.1 | 50 |
| S. aureus 33591 | 1.0 | 6.19 | 15 | 9.98 | 18 | 18.0 | 23 |
| Mean ± SD | 26 ± 8 | 33 ± 9 | 45 ± 13 | ||||
| E. coli 25922 | 0.125 | 5.64 | 36 | 8.92 | 41 | 15.4 | 48 |
| E. coli 1894-1 | 0.125 | 23.4 | 54 | 104 | 88 | >160 | |
| K. pneumoniae 43816 (thigh) | 0.125 | 21.6 | 53 | 51.5 | 74 | >400 | |
| K. pneumoniae 43816 (lung) | 37.6 | 64 | 124 | 91 | >400 | ||
| K. pneumoniae 216 | 0.125 | 12.5 | 45 | 53.2 | 75 | >160 | |
| Mean ± SD | 47 ± 8 | 69 ± 20 | |||||