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. 2014 Jun;20(6):846–854. doi: 10.1261/rna.043323.113

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© 2014 Rice et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 4. — Circle plots illustrating SHAPE-directed structure modeling for the glycine (top) and M-Box (bottom) riboswitches with 1M7 SHAPE data (left) and with 1M7 and differential reactivity data (right). Scheme for illustrating base-pair accuracy (relative to crystallographic structures) and nucleotide SHAPE reactivities are as outlined in Figure 3; positions with positive-amplitude (favoring NMIA) differential reactivities are indicated with a Δ symbol.