| Title: | Novel Compounds for the Treatment of Neurodegenerative Disease | ||
| Application Number: | WO 2012/080220 | Publication Date: | June 21, 2012 |
| Priority Application: | 1021104.3 | Priority Date: | December 13, 2010 |
| Inventors: | Griffioen, G.; van Dooren, T.; Rojas de la Parra, V.; Marchand, A.; Allasia, S.; Kilonda, A.; Chaltin, P. | ||
| Assignee Company: | Katholieke Universiteit Leuven, K.U. Leuven R 7D, Remynd | ||
| Disease Area: | Neurodegenerative disease | Biological Target: | Tau |
| Summary: | This application claims a series of indoles as molecules that inhibit tau phosphorylation. This approach to neurodegenerative disease is of interest because of the hypothesized role for tau in neuronal cell death. Tau is an intracellular protein that stabilizes microtubules and helps regulate their function, for example in cell division. Test compounds were studied for their ability to inhibit tau phosphorylation or inhibit α-synuclein in animals and in cell culture. | ||
| Primary Markush: |  |
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| Definitions: | E = CH or N; R1, R4–6 = H, halogen, OH, OR, SH, SR, SOnR, SO2NRR, amide, ester alkyl, unsaturated alkyl, aryl, heteroaryl (including substituted derivatives); R2 = H, alkyl, unsaturated alkyl; B = cyclic structure; R8 = as defined for R1/R4–6. | ||
| Notable Substructures: |  |
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| Biological Assay: | Data was reported using cell based assays to measure cytotoxicity. The specific cell based model used to provide the data above was not specified. | ||
The authors declare no competing financial interest.