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. 1996 Jan 9;93(1):485–490. doi: 10.1073/pnas.93.1.485

Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.

D R Sell 1, M A Lane 1, W A Johnson 1, E J Masoro 1, O B Mock 1, K M Reiser 1, J F Fogarty 1, R G Cutler 1, D K Ingram 1, G S Roth 1, V M Monnier 1
PMCID: PMC40263  PMID: 8552666

Abstract

A fundamental question in the basic biology of aging is whether there is a universal aging process. If indeed such a process exists, one would expect that it develops at a higher rate in short- versus long-lived species. We have quantitated pentosidine, a marker of glycoxidative stress in skin collagen from eight mammalian species as a function of age. A curvilinear increase was modeled for all species, and the rate of increase correlated inversely with maximum life-span. Dietary restriction, a potent intervention associated with increased life-span, markedly inhibited glycoxidation rate in the rodent. On the assumption that collagen turnover rate is primarily influenced by the crosslinking due to glycoxidation, these results suggest that there is a progressive age-related deterioration of the process that controls the collagen glycoxidation rate. Thus, the ability to withstand damage due to glycoxidation and the Maillard reaction may be under genetic control.

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Selected References

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