| Title: | Phenyl Carboxamide Analogues as Spleen Tyrosine Kinase (Syk) Inhibitors | ||
| Patent/Patent Application Number: | WO 2013052391 | Publication date: | April 11, 2013 |
| Priority Application: | US 2011/61543542 | Priority date: | October 5, 2011 |
| Inventors: | Altman, M. D.; Di Francesco, M. E.; Ellis, J. M.; Knowles, S. L.; Northrup, A. B. | ||
| Assignee Company: | Merck Sharp & Dohme Corp., USA | ||
| Disease Area: | Inflammatory, allergic, and autoimmune diseases | Biological Target: | Syk kinase |
| Summary: | The present application claims a series of phenyl carboxamide compounds that demonstrate activity against Syk kinase protein. Such compounds could potentially be used for the treatment of conditions or disorders associated with inappropriate Syk activity such as inflammatory, allergic, and autoimmune diseases (rheumatoid arthritis, asthma, etc.). | ||
| Important Compound Classes: |  |
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| Key Structures: |  |
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| Recent Review Articles: | Efremov D. G.; Laurenti L.. Expert Opin. Invest. Drugs 2011, 20, 623. | ||
| Biological Assay: | Compound efficacy was evaluated using a HTRF assay for the recombinant human Syk enzyme. | ||
| Pharmacological Data: |  |
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| Synthesis: | 18 compounds were synthesized. | ||
The authors declare no competing financial interest.