| Title: | Substituted Imidazothiazoles as Inhibitors of Viral Polymerase | ||
| Patent/Patent Application Number: | WO 2013075173, A1 | Publication date: | May, 30, 2013 |
| Priority Application: | US 2011-563688P | Priority date: | November 25, 2011 |
| Inventors: | Harding, M.; Bond, S. | ||
| Assignee Company: | Biota Scientific Management Pty. Ltd., Australia | ||
| Disease Area: | Hepatitic C Virus infection | Biological Target: | HCV Polymerase |
| Summary: | This application claims imidazothiazoles analogues for the treatment and prevention of viral infections, particularly HCV. Compounds described herein are inhibitors of HCV polymerase. | ||
| Important Compound Classes: |  |
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| Definitions | ----- Represent a single or double bond | ||
| X1 is selected from S, S=O, and S=O2 | |||
| Key Structures: |  |
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| Biological Assay: | Effect of compounds was evaluated using a HCV polymerase inhibition assay (41 compounds tested) and a HCV replicon assay (46 compounds tested). | ||
| Pharmacological Data: | Compounds efficacy in HCV polymerase inhibition and HCV replicon assays
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| Synthesis: | The synthesis of 54 compounds is described. | ||
The authors declare no competing financial interest.