Table 3.
Multiplicity and specificity of ligand binding by ITB subunits; ECM refers to extracellular matrix.
| ECM or Ligand | β Integrin subunit | Integrin Receptor/s |
|---|---|---|
| Collagens | β1 | α1β1, α2β1, α10β1, α11β1 |
| E-Cadherin | β1, β7 | αEβ7, α2β1 |
| Endorepellin | β1 | α2β1 |
| Endostatin | β1 | α5β1 |
| Factor X | β2 | αMβ 2 |
| Fibronectin | β1, β2, β3, β6 and β7 | α4β1, α5β1, α8β1, αvβ1, αIIbβ3, αvβ3, αvβ6, α4β7, αMβ2 |
| Fibrinogen | β2, β3 and β5 | αMβ2, αXβ2, αIIbβ3, αvβ3, αvβ5 |
| ICAM-1, -2, -3, -5 | β2 | αLβ2 |
| ICAM-3 | β2 | αDβ2 |
| iC3b | β2 | αMβ2, αXβ2 |
| Laminins | β1 and β4 | α1β1, α2β1, α3β1, α6β1, α6β4, α7β1, |
| MadCAM-1 | β7 | α4β7 |
| Nephronectin (RGD) | β1 | α8β1 |
| Osteopontin | β1, β3 and β5 | αvβ1, αvβ3, αvβ5 |
| Semaphorin 7A | β1 | α1β1 |
| Tenascin-C | β1, β3 and β6 | α1β1, α8β1, α9β1, αvβ3 and αvβ6 |
| TGF-β-LAP (RGD) | β6 and β8 | αvβ6, αvβ8 |
| Tumastatin | β3 | αvβ3 |
| VCAM-1 | β2 and β7 | αDβ2, α4β7, αHβ7 |
| VEGF-C, VEGF-D | β1 | α9β1 |
| Vitronectin | β1, β3, β5 and β8 | αvβ1, α8β1, αvβ3, αvβ5, αvβ8, , |
| Von Willebrandt Factor | β3 | αIIbβ3, αvβ3, |